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Wings Apart Like Protein (WAPAL)

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FOE; WAPL; Friend Of EBNA2

Wings Apart Like Protein (WAPAL)
CCC L833
HGNC 23293
MGI 2675859
PubMed 9039502
UniProt Q7Z5K2
Wiki WAPAL
The WAPAL protein contains 1,287 amino acids. By Northern blot analysis, moderate expression was detected in placenta, lung, liver, thymus, prostate, skeletal muscle, kidney, pancreas, spleen, testis, ovary, small intestine, and peripheral blood leukocytes with weak expression in heart, brain, and colon.
WAPAL contains an N-terminal arginine-rich motif (ARM), a bipartite nuclear localization sequence, 3 highly acidic domains, 4 predicted coiled-coil domains, and a C-terminal nuclear export signal. WAPAL shares shares 38% amino acid identity over the C-terminal region with the parallel sister chromatid product (PASC) of the Drosophila wapl gene. Northern blot analysis detected 6.5- and 4.4-kb transcripts in all human tissues examined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Wings Apart Like Protein (WAPAL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Wings Apart Like Protein (WAPAL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Wings Apart Like Protein (WAPAL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Wings Apart Like Protein (WAPAL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Wings Apart Like Protein (WAPAL) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Wings Apart Like Protein (WAPAL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Wings Apart Like Protein (WAPAL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Wings Apart Like Protein (WAPAL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Wings Apart Like Protein (WAPAL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Wings Apart Like Protein (WAPAL) ELISA Kit Customized Service Offer
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  2. "Identification and cloning of a novel chromatin-associated protein partner of Epstein-Barr nuclear protein 2."Exp. Cell Res. 300:223-233(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Wapl controls the dynamic association of cohesin with chromatin."Cell 127:955-967(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase."Curr. Biol. 16:2406-2417(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1."Genes Dev. 23:2224-2236(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Cohesin acetylation speeds the replication fork."Nature 462:231-234(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Sororin mediates sister chromatid cohesion by antagonizing wapl."Cell 143:737-749(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  20. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  22. "Structure of the human cohesin inhibitor Wapl."Proc. Natl. Acad. Sci. U.S.A. 110:11355-11360(2013) [PubMed] [Europe PMC] [Abstract]