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WW Domain Binding Protein 4 (WBP4)

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FBP21; FNBP21; Formin Binding Protein 21; WW domain-containing-binding protein 4

WW Domain Binding Protein 4 (WBP4)
CCC L832
HGNC 12739
MGI 109568
PubMed 22354037
RGD 620033
UniProt O75554
Wiki WBP4
WBP4 encodes WW domain-containing binding protein 4. The WW domain represents a small and compact globular structure that interacts with proline-rich ligands. This encoded protein is a general spliceosomal protein that may play a role in cross-intron bridging of U1 and U2 snRNPs in the spliceosomal complex A.
The predicted 376-amino acid FBP21 protein contains an N-terminal zinc finger motif and 2 WW domains. Western blot analysis of in vitro translated FBP21 protein and of HeLa cell extracts showed that FBP21 migrates as a 58-kD polypeptide. Immunofluorescence studies of HeLa cells indicated that endogenous FBP21 is exclusively localized to the nucleus and concentrated in a punctate pattern. In addition, FBP21 colocalized with the essential pre-mRNA splicing factor SC35.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WW Domain Binding Protein 4 (WBP4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WW Domain Binding Protein 4 (WBP4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WW Domain Binding Protein 4 (WBP4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WW Domain Binding Protein 4 (WBP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for WW Domain Binding Protein 4 (WBP4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WW Domain Binding Protein 4 (WBP4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WW Domain Binding Protein 4 (WBP4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WW Domain Binding Protein 4 (WBP4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WW Domain Binding Protein 4 (WBP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for WW Domain Binding Protein 4 (WBP4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WW Domain Binding Protein 4 (WBP4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WW Domain Binding Protein 4 (WBP4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WW Domain Binding Protein 4 (WBP4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WW Domain Binding Protein 4 (WBP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for WW Domain Binding Protein 4 (WBP4) ELISA Kit Customized Service Offer
  1. "WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif."Proc. Natl. Acad. Sci. U.S.A. 95:10602-10607(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  8. "Solution structure of WW domain in WW domain binding protein 4 (WBP-4)."Submitted (OCT-2006) to the PDB data bank
  9. "Structure and function of the two tandem WW domains of the pre-mRNA splicing factor FBP21 (formin-binding protein 21)."J. Biol. Chem. 284:25375-25387(2009) [PubMed] [Europe PMC] [Abstract]
  10. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]