WD Repeat And SOCS Box Containing Protein 1 (WSB1)
[Edit]SWIP1; WSB-1; SOCS box-containing WD protein SWiP-1
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WSB1 encodes a member of the WD-protein subfamily. This protein shares a high sequence identity to mouse and chick proteins. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.The deduced 421-amino acid protein contains 8 WD repeats, which span most of the protein, and a C-terminal SOCS box with a potential tyrosine phosphorylation site. Chicken and human SWIP1 share 88% amino acid identity. In addition, about 200 bp in the 3-prime UTRs of the human and chicken SWIP1 cDNAs share significant similarity.Swip1 transcription was regulated by Shh emitted by the notochord and was repressed by signals from the lateral plate. In limb bud, Swip1 was induced by ectopic Shh.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant WD Repeat And SOCS Box Containing Protein 1 (WSB1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to WD Repeat And SOCS Box Containing Protein 1 (WSB1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to WD Repeat And SOCS Box Containing Protein 1 (WSB1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | SEL825Hu | ELISA Kit for WD Repeat And SOCS Box Containing Protein 1 (WSB1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant WD Repeat And SOCS Box Containing Protein 1 (WSB1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to WD Repeat And SOCS Box Containing Protein 1 (WSB1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to WD Repeat And SOCS Box Containing Protein 1 (WSB1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for WD Repeat And SOCS Box Containing Protein 1 (WSB1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for WD Repeat And SOCS Box Containing Protein 1 (WSB1) | ELISA Kit Customized Service Offer |
- "SWiP-1: novel SOCS box containing WD-protein regulated by signalling centres and by Shh during development."Mech. Dev. 82:79-94(1999) [PubMed] [Europe PMC] [Abstract]
- "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
- "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
- "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases."Genes Dev. 18:3055-3065(2004) [PubMed] [Europe PMC] [Abstract]
- "The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate."Nat. Cell Biol. 7:698-705(2005) [PubMed] [Europe PMC] [Abstract]
- "Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1."J. Biol. Chem. 283:4682-4689(2008) [PubMed] [Europe PMC] [Abstract]