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Kidney And Brain Protein (KIBRA)

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WWC1; WW Domain Containing Protein 1; WW,C2 And Coiled-Coil Domain Containing 1; HBeAg-binding protein 3

Kidney And Brain Protein (KIBRA)
CCC L824
HGNC 29435
MGI 2388637
PubMed 22784093
RGD 1308329
UniProt Q8IX03
The deduced 1,113-amino acid protein has a calculated molecular mass of about 125 kD. It contains 2 N-terminal WW domains, and a C2-like domain and glutamine-rich domain in its C-terminal half. Northern blot analysis detected a major 4.3-kb transcript predominantly expressed in kidney and brain. Following expression in green monkey kidney cells, Western blot analysis detected human KIBRA and endogenous Kibra at an apparent molecular mass of 125 kD. Fluorescence microscopy localized KIBRA predominantly to the cytoplasm, with perinuclear enrichment.highest expression in liver and kidney, intermediate expression in brain, lung, pancreas, and ovary, weak expression in heart and testis, and no expression in skeletal muscle and spleen.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL824Hu01 Recombinant Kidney And Brain Protein (KIBRA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL824Hu01 Polyclonal Antibody to Kidney And Brain Protein (KIBRA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Kidney And Brain Protein (KIBRA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kidney And Brain Protein (KIBRA) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL824Mu01 Recombinant Kidney And Brain Protein (KIBRA) Positive Control; Immunogen; SDS-PAGE; WB.
RPL824Mu02 Recombinant Kidney And Brain Protein (KIBRA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL824Mu01 Polyclonal Antibody to Kidney And Brain Protein (KIBRA) WB; IHC; ICC; IP.
PAL824Mu02 Polyclonal Antibody to Kidney And Brain Protein (KIBRA) WB; IHC; ICC; IP.
Assay Kits SEL824Mu ELISA Kit for Kidney And Brain Protein (KIBRA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kidney And Brain Protein (KIBRA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kidney And Brain Protein (KIBRA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kidney And Brain Protein (KIBRA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kidney And Brain Protein (KIBRA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kidney And Brain Protein (KIBRA) ELISA Kit Customized Service Offer
  1. "Characterization of KIBRA, a novel WW domain-containing protein."Biochem. Biophys. Res. Commun. 300:862-867(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "KIBRA is a novel substrate for protein kinase Czeta."Biochem. Biophys. Res. Commun. 317:703-707(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Essential role of KIBRA in co-activator function of dynein light chain 1 in mammalian cells."J. Biol. Chem. 281:19092-19099(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Common Kibra alleles are associated with human memory performance."Science 314:475-478(2006) [PubMed] [Europe PMC] [Abstract]
  10. "SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment."Nat. Cell Biol. 9:1370-1380(2007) [PubMed] [Europe PMC] [Abstract]
  11. "KIBRA modulates directional migration of podocytes."J. Am. Soc. Nephrol. 19:1891-1903(2008) [PubMed] [Europe PMC] [Abstract]
  12. "KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling."Biochim. Biophys. Acta 1783:383-393(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Temporal-spatial expression and novel biochemical properties of the memory-related protein KIBRA."Neuroscience 155:1165-1173(2008) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded."Dev. Cell 18:288-299(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Kibra Is a regulator of the Salvador/Warts/Hippo signaling network."Dev. Cell 18:300-308(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Association of KIBRA with episodic and working memory: a meta-analysis."Am. J. Med. Genet. B Neuropsychiatr. Genet. 159B:958-969(2012) [PubMed] [Europe PMC] [Abstract]
  19. "Phospho-regulation of KIBRA by CDK1 and CDC14 phosphatase controls cell-cycle progression."Biochem. J. 447:93-102(2012) [PubMed] [Europe PMC] [Abstract]
  20. "Common exonic missense variants in the C2 domain of the human KIBRA protein modify lipid binding and cognitive performance." Transl. Psychiatry 3:E272-E272(2013) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  22. "Crystal structure of C2 domain of KIBRA protein."Submitted (FEB-2009) to the PDB data bank