≡

V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1)

[Edit]

P61-YES; Yes; c-yes; Proto-oncogene c-Yes; Tyrosine-protein kinase Yes

V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1)
CCC L807
HGNC 12841
MGI 99147
PubMed 2983418
RGD 3977
UniProt P07947
Wiki YES1
YES1 is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22.
The other 5 fragments could not be mapped either because hybridization signals were too weak or differentiation from mouse YES fragments was impossible. There was evidence for multiple copies of YES-related genes in the human genome, but only a single RNA species, 4.8 kb long, was found. At least 3 of the human YES gene copies had both introns and exons and 1 gene copy appeared to be a pseudogene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1) CLIA Kit Customized Service Offer
n/a ELISA Kit for V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1) CLIA Kit Customized Service Offer
n/a ELISA Kit for V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1) CLIA Kit Customized Service Offer
n/a ELISA Kit for V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1) ELISA Kit Customized Service Offer
  1. "Characterization of cDNA clones for the human c-yes gene."Mol. Cell. Biol. 7:41-47(1987) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 18." Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Distribution of c-yes-1 gene product in various cells and tissues."Br. J. Cancer 63:508-513(1991) [PubMed] [Europe PMC] [Abstract]
  5. "Differential expression of p62c-yes in normal, hyperplastic and neoplastic human epidermis."Oncogene 6:933-940(1991) [PubMed] [Europe PMC] [Abstract]
  6. "Palmitoylation of multiple Src-family kinases at a homologous N-terminal motif."Biochem. J. 303:749-753(1994) [PubMed] [Europe PMC] [Abstract]
  7. "Expression, purification, and initial characterization of human Yes protein tyrosine kinase from a bacterial expression system."Arch. Biochem. Biophys. 345:135-142(1997) [PubMed] [Europe PMC] [Abstract]
  8. "Autophosphorylation of Src and Yes blocks their inactivation by Csk phosphorylation."Oncogene 17:1587-1595(1998) [PubMed] [Europe PMC] [Abstract]
  9. "CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae."J. Cell Biol. 156:951-957(2002) [PubMed] [Europe PMC] [Abstract]
  10. "c-Yes response to growth factor activation."Growth Factors 23:263-272(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Phosphorylation of cyclin dependent kinase 4 on tyrosine 17 is mediated by Src family kinases."FEBS J. 275:3099-3109(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Phosphorylation of collapsin response mediator protein 2 on Tyr-479 regulates CXCL12-induced T lymphocyte migration."J. Biol. Chem. 284:13265-13276(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain."J. Cell Sci. 122:965-975(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Clues for c-Yes involvement in the cell cycle and cytokinesis."Cell Cycle 10:1502-1503(2011) [PubMed] [Europe PMC] [Abstract]
  19. "The naturally processed CD95L elicits a c-yes/calcium/PI3K-driven cell migration pathway."PLoS Biol. 9:E1001090-E1001090(2011) [PubMed] [Europe PMC] [Abstract]
  20. "Crystallographic structure of the SH3 domain of the human c-Yes tyrosine kinase: loop flexibility and amyloid aggregation."FEBS Lett. 581:1701-1706(2007) [PubMed] [Europe PMC] [Abstract]
  21. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]