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Presenilin Associated Metalloprotease (PAMP)

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FTSH; MEG4; YME1L1; YME1L; ATP-dependent metalloprotease FtsH1; YME1 Like Protein 1; ATP-dependent zinc metalloprotease YME1L1

Presenilin Associated Metalloprotease (PAMP)
CCC L805
HGNC 12843
MGI 1351651
PubMed 10843804
RGD 620764
UniProt Q96TA2
Wiki YME1L1
YME1L1 is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies. Two transcript variants encoding different isoforms have been found for this gene.
YME1L1 shares 50% sequence identity with yeast Yme1, 40% identity with yeast Rca1, and 39% identity with yeast Afg3, with highest homology in the central regions of the proteins. Northern blot analysis revealed transcripts of about 2.6 and 4.4 kb in all tissues examined, with greatest abundance in adult heart, skeletal muscle, and pancreas.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Presenilin Associated Metalloprotease (PAMP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Polyclonal Antibody Customized Service Offer
Assay Kits SEL805Hu ELISA Kit for Presenilin Associated Metalloprotease (PAMP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL805Mu01 Recombinant Presenilin Associated Metalloprotease (PAMP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Presenilin Associated Metalloprotease (PAMP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Presenilin Associated Metalloprotease (PAMP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Presenilin Associated Metalloprotease (PAMP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Presenilin Associated Metalloprotease (PAMP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Presenilin Associated Metalloprotease (PAMP) ELISA Kit Customized Service Offer
  1. "Identification and characterization of YME1L1, a novel paraplegin-related gene."Genomics 66:48-54(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Metalloprotease-mediated OPA1 processing is modulated by the mitochondrial membrane potential."Biol. Cell 100:315-325(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis and cell proliferation."Mol. Biol. Cell 23:1010-1023(2012) [PubMed] [Europe PMC] [Abstract]