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MYST Histone Acetyltransferase 3 (MYST3)

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MOZ; RUNXBP2; ZNF220; KAT6A; Runt-Related Transcription Factor Binding Protein 2; Monocytic Leukemia Zinc Finger Protein; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3

MYST Histone Acetyltransferase 3 (MYST3)
CCC L773
HGNC 13013
MGI 2442415
PubMed 20143402
RGD 1304892
UniProt Q92794
Wiki MYST3
MYST3 contains two nuclear localization domains, a C2HC3 zinc finger, and a acetyltransferase domain. This structure suggests that MYST3 functions as a chromatin-bound acetyltransferase.MYST3 is important for proper development of hematopoietic stem cells.The MOZ gene encodes a predicted 2,004-amino acid, 225-kD polypeptide with 2 bipartite nuclear localization domains. MOZ is a founding member of a group of highly conserved proteins characterized by a single C2HC3 zinc finger in conjunction with a putative acetyltransferase consensus domain. MOZ also contains two C4HC3 zinc finger domains, protein-interaction motifs associated with chromatin-bound proteins. These motifs suggested to the authors that MOZ may represent a chromatin-bound acetyltransferase.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MYST Histone Acetyltransferase 3 (MYST3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MYST Histone Acetyltransferase 3 (MYST3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MYST Histone Acetyltransferase 3 (MYST3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MYST Histone Acetyltransferase 3 (MYST3) CLIA Kit Customized Service Offer
n/a ELISA Kit for MYST Histone Acetyltransferase 3 (MYST3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MYST Histone Acetyltransferase 3 (MYST3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MYST Histone Acetyltransferase 3 (MYST3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MYST Histone Acetyltransferase 3 (MYST3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MYST Histone Acetyltransferase 3 (MYST3) CLIA Kit Customized Service Offer
n/a ELISA Kit for MYST Histone Acetyltransferase 3 (MYST3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MYST Histone Acetyltransferase 3 (MYST3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MYST Histone Acetyltransferase 3 (MYST3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MYST Histone Acetyltransferase 3 (MYST3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MYST Histone Acetyltransferase 3 (MYST3) CLIA Kit Customized Service Offer
n/a ELISA Kit for MYST Histone Acetyltransferase 3 (MYST3) ELISA Kit Customized Service Offer
  1. "The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein."Nat. Genet. 14:33-41(1996) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  3. "A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia."Blood 91:3127-3133(1998) [PubMed] [Europe PMC] [Abstract]
  4. "MOZ is fused to p300 in an acute monocytic leukemia with t(8;22)."Genes Chromosomes Cancer 28:138-144(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein."EMBO J. 20:7184-7196(2001) [PubMed] [Europe PMC] [Abstract]
  6. "The monocytic leukemia zinc finger protein MOZ is a histone acetyltransferase."Oncogene 20:404-409(2001) [PubMed] [Europe PMC] [Abstract]
  7. "MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2."Oncogene 21:2729-2740(2002) [PubMed] [Europe PMC] [Abstract]
  8. "MOZ-TIF2-induced acute myeloid leukemia requires the MOZ nucleosome binding motif and TIF2-mediated recruitment of CBP."Cancer Cell 3:259-271(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Transcriptional regulation of the human MIP-1alpha promoter by RUNX1 and MOZ."Nucleic Acids Res. 31:2735-2744(2003) [PubMed] [Europe PMC] [Abstract]
  10. "MOZ-TIF2 inhibits transcription by nuclear receptors and p53 by impairment of CBP function."Mol. Cell. Biol. 25:988-1002(2005) [PubMed] [Europe PMC] [Abstract]
  11. "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation."Mol. Cell 21:51-64(2006) [PubMed] [Europe PMC] [Abstract]
  12. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes."Mol. Cell. Biol. 28:6828-6843(2008) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "MOZ increases p53 acetylation and premature senescence through its complex formation with PML."Proc. Natl. Acad. Sci. U.S.A. 110:3895-3900(2013) [PubMed] [Europe PMC] [Abstract]
  19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  20. "Solution structure of a CCCCCHC zinc finger from MOZ."Submitted (JUN-2002) to the PDB data bank
  21. "The human monocytic leukemia zinc finger histone acetyltransferase domain contains DNA-binding activity implicated in chromatin targeting."J. Biol. Chem. 282:36603-36613(2007) [PubMed] [Europe PMC] [Abstract]
  22. "The crystal structure of human MYST histone acetyltransferase 3 in complex with acetylcoenzyme A."Submitted (FEB-2009) to the PDB data bank