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MYST Histone Acetyltransferase 2 (MYST2)

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HBO1; HBOA; KAT7; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2; Lysine acetyltransferase 7; Histone acetyltransferase binding to ORC1

MYST Histone Acetyltransferase 2 (MYST2)
CCC L772
HGNC 17016
MGI 2182799
PubMed 21149574
RGD 727966
UniProt O95251
Wiki MYST2
MYST2 encodes a 611-amino acid protein with a predicted molecular mass of 83 kD. MYST2 contains an N-terminal serine-rich region, and a C-terminal MYST domain that includes a putative acetyl-CoA-binding domain. Northern blot analysis showed ubiquitous expression of a MYST2 transcript, with high expression levels in ovarian tissue.
The in vitro and in vivo binding of ORC1 with MYST2 was confirmed by a variety of immunoprecipitation assays.The in vitro and in vivo binding of AR with MYST2 was confirmed by a variety of immunoprecipitation assays, and deletion construct experiments mapped the AR-interaction domain to the C terminus of MYST2. Transient transfection assays showed that MYST2 inhibited AR-mediated transactivation of reporter constructs in CV-1 and PC-3 cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MYST Histone Acetyltransferase 2 (MYST2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MYST Histone Acetyltransferase 2 (MYST2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MYST Histone Acetyltransferase 2 (MYST2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MYST Histone Acetyltransferase 2 (MYST2) CLIA Kit Customized Service Offer
n/a ELISA Kit for MYST Histone Acetyltransferase 2 (MYST2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MYST Histone Acetyltransferase 2 (MYST2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MYST Histone Acetyltransferase 2 (MYST2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MYST Histone Acetyltransferase 2 (MYST2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MYST Histone Acetyltransferase 2 (MYST2) CLIA Kit Customized Service Offer
n/a ELISA Kit for MYST Histone Acetyltransferase 2 (MYST2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MYST Histone Acetyltransferase 2 (MYST2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MYST Histone Acetyltransferase 2 (MYST2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MYST Histone Acetyltransferase 2 (MYST2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MYST Histone Acetyltransferase 2 (MYST2) CLIA Kit Customized Service Offer
n/a ELISA Kit for MYST Histone Acetyltransferase 2 (MYST2) ELISA Kit Customized Service Offer
  1. "Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein."J. Biol. Chem. 274:23027-23034(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Androgen receptor interacts with a novel MYST protein, HBO1."J. Biol. Chem. 275:35200-35208(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1."J. Biol. Chem. 276:15397-15408(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation."Mol. Cell 21:51-64(2006) [PubMed] [Europe PMC] [Abstract]
  9. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  10. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Role for Plk1 phosphorylation of Hbo1 in regulation of replication licensing."Proc. Natl. Acad. Sci. U.S.A. 105:1919-1924(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]