≡

Myelin Protein Zero Like Protein 1 (MPZL1)

[Edit]

PZR; PZR1b; PZRa; PZRb; Protein zero-related

Myelin Protein Zero Like Protein 1 (MPZL1)
CCC L753
HGNC 7226
MGI 1915731
PubMed 16702974
RGD 1359140
UniProt O95297
Wiki MPZL1
MPZL1 could be dephosphorylated by PTPN11 but not by PTPN6, which has a negative role in the proliferation of hematopoietic cells. Sequence homology analysis revealed 45.8% identity with myelin protein zero. The predicted protein contains an amino-terminal signal sequence and a single membrane-spanning segment. The extracellular portion forms an Ig-like domain with potential N-linked glycosylation sites. The intracellular portion contains an ITIM consensus sequence, a motif observed in another potential PTPN11 substrate, PTPNS1. Northern blot analysis revealed expression of PZR as a major, approximately 4.0-kb transcript and minor 3.8- and 1.3-kb transcripts in all tissues tested, with highest expression in heart, placenta, kidney, and pancreas.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myelin Protein Zero Like Protein 1 (MPZL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myelin Protein Zero Like Protein 1 (MPZL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myelin Protein Zero Like Protein 1 (MPZL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myelin Protein Zero Like Protein 1 (MPZL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myelin Protein Zero Like Protein 1 (MPZL1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myelin Protein Zero Like Protein 1 (MPZL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myelin Protein Zero Like Protein 1 (MPZL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myelin Protein Zero Like Protein 1 (MPZL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myelin Protein Zero Like Protein 1 (MPZL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myelin Protein Zero Like Protein 1 (MPZL1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myelin Protein Zero Like Protein 1 (MPZL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myelin Protein Zero Like Protein 1 (MPZL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myelin Protein Zero Like Protein 1 (MPZL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myelin Protein Zero Like Protein 1 (MPZL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myelin Protein Zero Like Protein 1 (MPZL1) ELISA Kit Customized Service Offer
  1. "Purification and cloning of PZR, a binding protein and putative physiological substrate of tyrosine phosphatase SHP-2."J. Biol. Chem. 273:29367-29372(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning of human myelin protein zero-like genes by bioinformatics strategy."Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 32:364-368(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of a variant form of PZR lacking immunoreceptor tyrosine-based inhibitory motifs."Biochem. Biophys. Res. Commun. 303:1028-1033(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Novel mesenchymal and haematopoietic cell isoforms of the SHP-2 docking receptor, PZR: identification, molecular cloning and effects on cell migration."Biochem. J. 370:537-549(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Dissecting the interaction of SHP-2 with PZR, an immunoglobulin family protein containing immunoreceptor tyrosine-based inhibitory motifs."J. Biol. Chem. 275:5453-5459(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Cell surface glycoprotein PZR is a major mediator of concanavalin A-induced cell signaling."J. Biol. Chem. 277:7882-7888(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]