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Carbohydrate Response Element Binding Protein (CHREBP)

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MLXIPL; MIO; MONDOB; WBSCR14; WS-bHLH; MLX Interacting Protein Like Protein; Williams-Beuren Syndrome Chromosomal Region 14 Protein

Carbohydrate Response Element Binding Protein (CHREBP)
CCC L745
HGNC 12744
MGI 1927999
PubMed 18193046
UniProt Q9NP71
Wiki MLXIPL
MLXIPL encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes.
WBSCR14 was expressed in multiple tissues, including regions of the brain and the intestinal tract. WBSCR14 formed heterodimers with the bHLH-ZIP protein Mlx to bind the DNA sequence CACGTG. Like Max, Mlx has no intrinsic transcriptional activity, but its association with Mad1, Mad4, Mnt, or WBSCR14 can repress E-box-dependent transcription. Preliminary results suggested a possible role of WBSCR14 in growth control.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carbohydrate Response Element Binding Protein (CHREBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carbohydrate Response Element Binding Protein (CHREBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carbohydrate Response Element Binding Protein (CHREBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carbohydrate Response Element Binding Protein (CHREBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbohydrate Response Element Binding Protein (CHREBP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carbohydrate Response Element Binding Protein (CHREBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carbohydrate Response Element Binding Protein (CHREBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carbohydrate Response Element Binding Protein (CHREBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carbohydrate Response Element Binding Protein (CHREBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbohydrate Response Element Binding Protein (CHREBP) ELISA Kit Customized Service Offer
  1. "WBSCR14, a putative transcription factor gene deleted in Williams-Beuren syndrome: complete characterisation of the human gene and the mouse ortholog."Eur. J. Hum. Genet. 8:215-222(2000) [PubMed] [Europe PMC] [Abstract]
  2. "WBSCR14, a gene mapping to the Williams-Beuren syndrome deleted region, is a new member of the Mlx transcription factor network."Hum. Mol. Genet. 10:617-627(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete physical map of the common deletion region in Williams syndrome and identification and characterization of three novel genes."Hum. Genet. 103:590-599(1998) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]