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Myeloid/Lymphoid Or Mixed Lineage Leukemia (MLL)

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ALL-1; CXXC7; HRX; HTRX1; MLL/GAS7; MLL1A; TRX1; KMT2A; CXXC-type zinc finger protein 7; Myeloid/lymphoid or mixed-lineage leukemia; Trithorax-like protein

Myeloid/Lymphoid Or Mixed Lineage Leukemia (MLL)
CCC L739
HGNC 7132
MGI 96995
PubMed 22623725
RGD 1586165
UniProt Q03164
Wiki MLL
MLL is a frequent target for recurrent translocations in acute leukemias that may be characterized as acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), or mixed lineage (biphenotypic) leukemia (MLL). Leukemias with translocations involving MLL possess unique clinical and biologic characteristics and are often associated with poor prognosis. MLL rearrangements are found in more than 70% of infant leukemias, whether the immunophenotype is more consistent with ALL or AML6, but are less frequent in leukemias from older children. MLL translocations are also found in approximately 10% of AMLs in adults, as well as in therapy-related leukemias, most often characterized as AML, that develop in patients previously treated with topoisomerase II inhibitors for other malignancies.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myeloid/Lymphoid Or Mixed Lineage Leukemia (MLL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myeloid/Lymphoid Or Mixed Lineage Leukemia (MLL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myeloid/Lymphoid Or Mixed Lineage Leukemia (MLL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myeloid/Lymphoid Or Mixed Lineage Leukemia (MLL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myeloid/Lymphoid Or Mixed Lineage Leukemia (MLL) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myeloid/Lymphoid Or Mixed Lineage Leukemia (MLL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myeloid/Lymphoid Or Mixed Lineage Leukemia (MLL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myeloid/Lymphoid Or Mixed Lineage Leukemia (MLL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myeloid/Lymphoid Or Mixed Lineage Leukemia (MLL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myeloid/Lymphoid Or Mixed Lineage Leukemia (MLL) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myeloid/Lymphoid Or Mixed Lineage Leukemia (MLL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myeloid/Lymphoid Or Mixed Lineage Leukemia (MLL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myeloid/Lymphoid Or Mixed Lineage Leukemia (MLL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myeloid/Lymphoid Or Mixed Lineage Leukemia (MLL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myeloid/Lymphoid Or Mixed Lineage Leukemia (MLL) ELISA Kit Customized Service Offer
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  2. "Exon/intron structure of the human ALL-1 (MLL) gene involved in translocations to chromosomal region 11q23 and acute leukaemias."Br. J. Haematol. 93:966-972(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  4. "Two distinct portions of LTG19/ENL at 19p13 are involved in t(11;19) leukemia."Oncogene 8:2617-2625(1993) [PubMed] [Europe PMC] [Abstract]
  5. "The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene."Cell 71:701-708(1992) [PubMed] [Europe PMC] [Abstract]
  6. "A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias."Nat. Genet. 2:113-118(1992) [PubMed] [Europe PMC] [Abstract]
  7. ErratumNat. Genet. 4:431-431(1993) [PubMed] [Europe PMC] [Abstract]
  8. "Molecular analysis of the chromosomal breakpoint and fusion transcripts in the acute lymphoblastic SEM cell line with chromosomal translocation t(4;11)."Br. J. Haematol. 90:308-320(1995) [PubMed] [Europe PMC] [Abstract]
  9. "The human MLL gene: nucleotide sequence, homology to the Drosophila trx zinc-finger domain, and alternative splicing."DNA Cell Biol. 14:475-483(1995) [PubMed] [Europe PMC] [Abstract]
  10. "Sequence analysis of the breakpoint cluster region in the ALL-1 gene involved in acute leukemia."Cancer Res. 54:2327-2330(1994) [PubMed] [Europe PMC] [Abstract]
  11. "Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors."Proc. Natl. Acad. Sci. U.S.A. 97:2814-2819(2000) [PubMed] [Europe PMC] [Abstract]
  12. "A method for identifying genes within yeast artificial chromosomes: application to isolation of MLL fusion cDNAs from acute leukaemia translocations."Oncogene 8:3157-3160(1993) [PubMed] [Europe PMC] [Abstract]
  13. "Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization."Mol. Cell. Biol. 23:186-194(2003) [PubMed] [Europe PMC] [Abstract]
  14. "Fusion of the MLL gene with two different genes, AF-6 and AF-5alpha, by a complex translocation involving chromosomes 5, 6, 8 and 11 in infant leukemia."Oncogene 13:2121-2130(1996) [PubMed] [Europe PMC] [Abstract]
  15. "ABI-1, a human homolog to mouse Abl-interactor 1, fuses the MLL gene in acute myeloid leukemia with t(10;11)(p11.2;q23)."Blood 92:1125-1130(1998) [PubMed] [Europe PMC] [Abstract]
  16. "Association of SET domain and myotubularin-related proteins modulates growth control."Nat. Genet. 18:331-337(1998) [PubMed] [Europe PMC] [Abstract]
  17. "Leukemic HRX fusion proteins inhibit GADD34-induced apoptosis and associate with the GADD34 and hSNF5/INI1 proteins."Mol. Cell. Biol. 19:7050-7060(1999) [PubMed] [Europe PMC] [Abstract]
  18. "AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23)."Proc. Natl. Acad. Sci. U.S.A. 96:14535-14540(1999) [PubMed] [Europe PMC] [Abstract]
  19. "Novel SH3 protein encoded by the AF3p21 gene is fused to the mixed lineage leukemia protein in a therapy-related leukemia with t(3;11)(p21;q23)."Blood 95:1066-1068(2000) [PubMed] [Europe PMC] [Abstract]
  20. "t(3;11) translocation in treatment-related acute myeloid leukemia fuses MLL with the GMPS (guanosine 5-prime monophosphate synthetase) gene."Blood 96:4360-4362(2000) [PubMed] [Europe PMC] [Abstract]
  21. "Human LPP gene is fused to MLL in a secondary acute leukemia with a t(3;11) (q28;q23)."Genes Chromosomes Cancer 31:382-389(2001) [PubMed] [Europe PMC] [Abstract]
  22. "LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23)."Cancer Res. 62:4075-4080(2002) [PubMed] [Europe PMC] [Abstract]
  23. "ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation."Mol. Cell 10:1119-1128(2002) [PubMed] [Europe PMC] [Abstract]
  24. "Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression."Cell 115:293-303(2003) [PubMed] [Europe PMC] [Abstract]
  25. "A t(11;15) fuses MLL to two different genes, AF15q14 and a novel gene MPFYVE on chromosome 15."Oncogene 22:1400-1410(2003) [PubMed] [Europe PMC] [Abstract]
  26. "Characterization of the MLL partner gene AF15q14 involved in t(11;15)(q23;q14)."Oncogene 22:1418-1424(2003) [PubMed] [Europe PMC] [Abstract]
  27. "Identification of a novel RAS GTPase-activating protein (RASGAP) gene at 9q34 as an MLL fusion partner in a patient with de novo acute myeloid leukemia."Genes Chromosomes Cancer 39:324-334(2004) [PubMed] [Europe PMC] [Abstract]
  28. "FLJ10849, a septin family gene, fuses MLL in a novel leukemia cell line CNLBC1 derived from chronic neutrophilic leukemia in transformation with t(4;11)(q21;q23)."Leukemia 18:998-1005(2004) [PubMed] [Europe PMC] [Abstract]
  29. "Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression."Mol. Cell. Biol. 24:5639-5649(2004) [PubMed] [Europe PMC] [Abstract]
  30. "AF4p12, a human homologue to the furry gene of Drosophila, as a novel MLL fusion partner."Cancer Res. 65:6521-6525(2005) [PubMed] [Europe PMC] [Abstract]
  31. "Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF."Cell 121:873-885(2005) [PubMed] [Europe PMC] [Abstract]
  32. "Nine-amino-acid transactivation domain: establishment and prediction utilities."Genomics 89:756-768(2007) [PubMed] [Europe PMC] [Abstract]
  33. "PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex."J. Biol. Chem. 282:20395-20406(2007) [PubMed] [Europe PMC] [Abstract]
  34. "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells."J. Proteome Res. 6:298-305(2007) [PubMed] [Europe PMC] [Abstract]
  35. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  36. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  37. "On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex."J. Biol. Chem. 284:24242-24256(2009) [PubMed] [Europe PMC] [Abstract]
  38. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  39. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  40. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  41. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  42. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  43. "De novo mutations in MLL cause Wiedemann-Steiner syndrome."Am. J. Hum. Genet. 91:358-364(2012) [PubMed] [Europe PMC] [Abstract]
  44. "Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proliferation and differentiation."Cell 151:1097-1112(2012) [PubMed] [Europe PMC] [Abstract]
  45. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  46. "Solution structure of the nonmethyl-CpG-binding CXXC domain of the leukaemia-associated MLL histone methyltransferase."EMBO J. 25:4503-4512(2006) [PubMed] [Europe PMC] [Abstract]
  47. "Structural basis for cooperative transcription factor binding to the CBP coactivator."J. Mol. Biol. 355:1005-1013(2006) [PubMed] [Europe PMC] [Abstract]
  48. "Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide."J. Biol. Chem. 283:32158-32161(2008) [PubMed] [Europe PMC] [Abstract]
  49. "Structural basis for the requirement of additional factors for MLL1 SET domain activity and recognition of epigenetic marks."Mol. Cell 33:181-191(2009) [PubMed] [Europe PMC] [Abstract]