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MutL Homolog 3 (MLH3)

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HNPCC7; DNA mismatch repair protein Mlh3

MutL Homolog 3 (MLH3)
CCC L736
HGNC 7128
MGI 1353455
PubMed 10615123
RGD 1309227
UniProt Q9UHC1
Wiki MLH3
MLH3 is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). MLH3 is more similar to mismatch repair proteins from yeast, plants, worms, and bacteria than to any known mammalian protein, suggesting that its conserved sequence may confer unique functions in mice and humans. Cells in culture stably expressing a dominant-negative MLH3 protein exhibited microsatellite instability.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MutL Homolog 3 (MLH3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MutL Homolog 3 (MLH3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MutL Homolog 3 (MLH3) Polyclonal Antibody Customized Service Offer
Assay Kits SEL736Hu ELISA Kit for MutL Homolog 3 (MLH3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MutL Homolog 3 (MLH3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MutL Homolog 3 (MLH3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MutL Homolog 3 (MLH3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MutL Homolog 3 (MLH3) CLIA Kit Customized Service Offer
n/a ELISA Kit for MutL Homolog 3 (MLH3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MutL Homolog 3 (MLH3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MutL Homolog 3 (MLH3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MutL Homolog 3 (MLH3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MutL Homolog 3 (MLH3) CLIA Kit Customized Service Offer
n/a ELISA Kit for MutL Homolog 3 (MLH3) ELISA Kit Customized Service Offer
  1. "MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability."Nat. Genet. 24:27-35(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The interacting domains of three MutL heterodimers in man: hMLH1 interacts with 36 homologous amino acid residues within hMLH3, hPMS1 and hPMS2."Nucleic Acids Res. 29:1695-1702(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease." Nature 375:754-760(1995) [PubMed] [Europe PMC] [Abstract]
  5. "Germline and somatic mutation analyses in the DNA mismatch repair gene MLH3: evidence for somatic mutation in colorectal cancers."Hum. Mutat. 17:389-396(2001) [PubMed] [Europe PMC] [Abstract]
  6. "A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair."Mol. Cell 39:36-47(2010) [PubMed] [Europe PMC] [Abstract]
  7. "A role for MLH3 in hereditary nonpolyposis colorectal cancer."Nat. Genet. 29:137-138(2001) [PubMed] [Europe PMC] [Abstract]