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MBD2 Interacting Zinc Finger Protein (MIZF)

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HiNF-P; ZNF743; HINFP; Histone H4 Transcription Factor; Histone Nuclear Factor P; Methyl-CpG-binding protein 2-interacting zinc finger protein

MBD2 Interacting Zinc Finger Protein (MIZF)
CCC L731
HGNC 17850
MGI 2429620
PubMed 11553631
UniProt Q9BQA5
Wiki MIZF
MIZF interacts with methyl-CpG-binding protein-2 (MBD2), a component of the MeCP1 histone deacetylase (HDAC) complex, and plays a role in DNA methylation and transcription repression.
The deduced 517 amino acid protein has a calculated molecular mass of 59.7 kD and is predicted to contain 7 zinc finger domains similar to the C2H2 zinc finger motif, and a stretch of negatively charged amino acids. Northern blot analysis revealed ubiquitous expression of an approximately 2.3-kb transcript at highest levels in brain, heart, skeletal muscle, and kidney, and moderate levels in colon, thymus, spleen, liver, small intestine, placenta, and lung. Immunolocalization of MIZF transfected into COS-7 cells revealed staining in all areas of the nucleus except the nucleolus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MBD2 Interacting Zinc Finger Protein (MIZF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MBD2 Interacting Zinc Finger Protein (MIZF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MBD2 Interacting Zinc Finger Protein (MIZF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MBD2 Interacting Zinc Finger Protein (MIZF) CLIA Kit Customized Service Offer
n/a ELISA Kit for MBD2 Interacting Zinc Finger Protein (MIZF) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MBD2 Interacting Zinc Finger Protein (MIZF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MBD2 Interacting Zinc Finger Protein (MIZF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MBD2 Interacting Zinc Finger Protein (MIZF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MBD2 Interacting Zinc Finger Protein (MIZF) CLIA Kit Customized Service Offer
n/a ELISA Kit for MBD2 Interacting Zinc Finger Protein (MIZF) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2."J. Biol. Chem. 276:42632-42638(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of HiNF-P, a key activator of cell cycle-controlled histone H4 genes at the onset of S phase."Mol. Cell. Biol. 23:8110-8123(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Sequence-specific transcriptional repression by an MBD2-interacting zinc finger protein MIZF."Nucleic Acids Res. 32:590-597(2004) [PubMed] [Europe PMC] [Abstract]
  8. "HiNF-P directly links the cyclin E/CDK2/p220NPAT pathway to histone H4 gene regulation at the G1/S phase cell cycle transition."Mol. Cell. Biol. 25:6140-6153(2005) [PubMed] [Europe PMC] [Abstract]
  9. "The histone gene transcription factor HiNF-P stabilizes its cell cycle regulatory co-activator p220NPAT."Biochemistry 45:15915-15920(2006) [PubMed] [Europe PMC] [Abstract]
  10. "The HiNF-P/p220NPAT cell cycle signaling pathway controls nonhistone target genes."Cancer Res. 67:10334-10342(2007) [PubMed] [Europe PMC] [Abstract]
  11. "HiNF-P is a bifunctional regulator of cell cycle controlled histone H4 gene transcription."J. Cell. Biochem. 101:181-191(2007) [PubMed] [Europe PMC] [Abstract]
  12. "The histone gene cell cycle regulator HiNF-P is a unique zinc finger transcription factor with a novel conserved auxiliary DNA-binding motif."Biochemistry 47:11415-11423(2008) [PubMed] [Europe PMC] [Abstract]