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Mindbomb Homolog 1 (MIB1)

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DIP-1; MIB; ZZANK2; ZZZ6; Mind bomb homolog 1; DAPK-interacting protein 1; E3 ubiquitin-protein ligase MIB1; Zinc finger ZZ type with ankyrin repeat domain protein 2

Mindbomb Homolog 1 (MIB1)
CCC L727
HGNC 21086
MGI 2443157
PubMed 23314057
RGD 1307195
UniProt Q86YT6
Wiki MIB1
The DIP1 transcript contains a 3-prime repeat sequence. RT-PCR ELISA detected moderate to high DIP1 expression in all tissues examined, with highest levels in spinal cord, ovary, whole brain, and all specific brain regions examined.deduced 1,006-amino acid protein contains a zinc finger, 9 ankyrin repeats, 3 RING fingers, and an alpha-helical coiled-coil region between RING2 and RING3. Northern blot analysis detected a 4.0-kb transcript in all mouse tissues analyzed. HeLa cells transiently expressing mouse Dip1 or only the Dip1 RING finger motifs showed DNA fragmentation characteristic of apoptotic changes. Overexpression of Dip1 abolished the antiapoptotic effect of Dapk expression. Dip1 regulated the cellular levels of Dapk through its E3 ubiquitin ligase activity, which promoted ubiquitination of Dapk in vitro and in vivo.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL727Hu01 Recombinant Mindbomb Homolog 1 (MIB1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL727Hu01 Polyclonal Antibody to Mindbomb Homolog 1 (MIB1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Mindbomb Homolog 1 (MIB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mindbomb Homolog 1 (MIB1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mindbomb Homolog 1 (MIB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mindbomb Homolog 1 (MIB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mindbomb Homolog 1 (MIB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mindbomb Homolog 1 (MIB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mindbomb Homolog 1 (MIB1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mindbomb Homolog 1 (MIB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mindbomb Homolog 1 (MIB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mindbomb Homolog 1 (MIB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mindbomb Homolog 1 (MIB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mindbomb Homolog 1 (MIB1) ELISA Kit Customized Service Offer
  1. "Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta."Dev. Cell 4:67-82(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Death-associated protein kinase expression in human temporal lobe epilepsy."Ann. Neurol. 55:485-494(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Mapping a dynamic innate immunity protein interaction network regulating type I interferon production."Immunity 35:426-440(2011) [PubMed] [Europe PMC] [Abstract]
  8. "A new cellular stress response that triggers centriolar satellite reorganization and ciliogenesis."EMBO J. 32:3029-3040(2013) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Diagnostic exome sequencing in persons with severe intellectual disability."N. Engl. J. Med. 367:1921-1929(2012) [PubMed] [Europe PMC] [Abstract]
  11. "Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy." Nat. Med. 19:193-201(2013) [PubMed] [Europe PMC] [Abstract]