Ring Finger And KH Domain Containing Protein 1 (RKHD1)

MEX3D is an RNA binding protein that interacts with AU-rich elements of Bcl-2. Upon binding, MEX3D has a negative regulatory action on Bcl-2 expression at the posttranscriptional level.MEX3 proteins contain two N-terminal heterogeneous nuclear ribonucleoprotein K homology motifs and a RING domain at the C-terminus.The predicted 490-amino acid partial protein has 2 N-terminal ribonucleoprotein K homology (KH) domains and a C-terminal RING domain, and it shares similarity with C. elegans Mex3. Northern blot analysis detected a 3.1-kb transcript in all tissues examined, with highest expression in placenta. A 6.5-kb transcript was also present in heart and skeletal muscle. Immunofluorescence analysis of HeLa cells localized endogenous TINO predominantly in the nucleus and perinuclear region.