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MYC Induced Nuclear Antigen (MINA)

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MDIG; NO52; MINA53; ROX; Mineral dust-induced gene protein; Nucleolar protein 52; 60S ribosomal protein L27a histidine hydroxylase; Ribosomal oxygenase MINA

MYC Induced Nuclear Antigen (MINA)
CCC L720
HGNC 19441
MGI 1914264
PubMed 12091391
RGD 708521
UniProt Q8IUF8
Wiki MINA
The deduced 465-amino acid protein has a calculated molecular mass of 52.7 kD. Additional alternative splice forms were isolated and correspond to a deduced protein of 464 amino acids lacking gln297 and a species containing a 101-bp insertion, deduced to contain the N-terminal 262 amino acids followed by 18 novel residues.
MINA shares 72% and 75% amino acid identity with the corresponding mouse and rat orthologs, respectively. Immunofluorescence studies localized MINA to the nucleus in a diffuse pattern with some distribution in a strong dotted staining pattern, corresponding to a nucleolar localization. Northern blot analysis detected a 5-fold increase in MINA expression after serum stimulation of serum-starved T98G glioblastoma cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MYC Induced Nuclear Antigen (MINA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MYC Induced Nuclear Antigen (MINA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MYC Induced Nuclear Antigen (MINA) Polyclonal Antibody Customized Service Offer
Assay Kits SEL720Hu ELISA Kit for MYC Induced Nuclear Antigen (MINA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MYC Induced Nuclear Antigen (MINA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MYC Induced Nuclear Antigen (MINA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MYC Induced Nuclear Antigen (MINA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MYC Induced Nuclear Antigen (MINA) CLIA Kit Customized Service Offer
n/a ELISA Kit for MYC Induced Nuclear Antigen (MINA) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MYC Induced Nuclear Antigen (MINA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MYC Induced Nuclear Antigen (MINA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MYC Induced Nuclear Antigen (MINA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MYC Induced Nuclear Antigen (MINA) CLIA Kit Customized Service Offer
n/a ELISA Kit for MYC Induced Nuclear Antigen (MINA) ELISA Kit Customized Service Offer
  1. "A novel myc target gene, mina53, that is involved in cell proliferation."J. Biol. Chem. 277:35450-35459(2002) [PubMed] [Europe PMC] [Abstract].
  2. "NO66, a highly conserved dual location protein in the nucleolus and in a special type of synchronously replicating chromatin."Mol. Biol. Cell 15:1816-1832(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer."Oncogene 24:4873-4882(2005) [PubMed] [Europe PMC] [Abstract] and Lung cancer.
  4. "MDIG gene, a potential biomarker for human lung cancer."Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract].
  6. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract].
  8. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Increased expression of a Myc target gene Mina53 in human colon cancer."Am. J. Pathol. 164:205-216(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Mina53 as a potential prognostic factor for esophageal squamous cell carcinoma."Clin. Cancer Res. 10:7347-7356(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Protein NO52 -- a constitutive nucleolar component sharing high sequence homologies to protein NO66."Eur. J. Cell Biol. 84:279-294(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Immunohistochemical expression of Mina53 and Ki67 proteins in human primary gingival squamous cell carcinoma."Kurume Med. J. 53:71-78(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Lung cancer-associated JmjC domain protein mdig suppresses formation of tri-methyl lysine 9 of histone H3."Cell Cycle 8:2101-2109(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans." Nat. Chem. Biol. 8:960-962(2012) [PubMed] [Europe PMC] [Abstract]