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Tricellulin (TRIC)

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MARVELD2; DFNB49; MARVD2; MRVLDC2; MARVEL Domain Containing Protein 2; Deafness,Autosomal Recessive 49

Tricellulin (TRIC)
CCC L710
HGNC 26401
MGI 2446166
PubMed 16365161
RGD 1306909
UniProt Q8N4S9
MARVELD2, or tricellulin (TRIC), is an integral membrane protein concentrated at the vertically oriented TJ strands of tricellular contacts.The 555-amino acid protein contains cytoplasmic N and C termini, 2 transmembrane domains, and 2 extracellular loops. Northern blot analysis detected high expression of Tric in epithelium-derived tissues, including small intestine, kidney, and lung. Western blot analysis of mouse epithelial cell lines revealed an approximately 66-kD protein, as well as larger phosphorylated intracellular forms. Immunofluorescence microscopy showed expression of Tric predominantly at tricellular contacts where occludin (OCLN)-positive bicellular TJs converged. Tric-positive structures appeared as short rods through confocal microscopy.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL710Hu01 Recombinant Tricellulin (TRIC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Tricellulin (TRIC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tricellulin (TRIC) Polyclonal Antibody Customized Service Offer
Assay Kits SEL710Hu ELISA Kit for Tricellulin (TRIC) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tricellulin (TRIC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tricellulin (TRIC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tricellulin (TRIC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tricellulin (TRIC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tricellulin (TRIC) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tricellulin (TRIC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tricellulin (TRIC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tricellulin (TRIC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tricellulin (TRIC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tricellulin (TRIC) ELISA Kit Customized Service Offer
  1. "Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells."J. Cell Biol. 171:939-945(2005) [PubMed] [Europe PMC] [Abstract]
  2. "Tricellulin is a tight-junction protein necessary for hearing."Am. J. Hum. Genet. 79:1040-1051(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]