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Mitogen Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1)

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IB1; JIP-1; JIP1; PRKM8IP; C-Jun-amino-terminal kinase-interacting protein 1; Islet-brain 1; JNK MAP kinase scaffold protein 1

Mitogen Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1)
CCC L706
HGNC 6882
MGI 1309464
PubMed 10700186
RGD 70937
UniProt Q9UQF2
Wiki MAPK8IP1
MAPK8IP1 encoded by this gene is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells.
This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) ELISA Kit Customized Service Offer
  1. "Genomic organization, fine-mapping, and expression of the human islet-brain 1 (IB1)/C-jun-amino-terminal kinase interacting protein-1 (JIP-1) gene."Genomics 55:202-208(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons."J. Biol. Chem. 274:35113-35118(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules."J. Cell Biol. 152:959-970(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway."J. Biochem. 130:773-781(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Interaction of Alzheimer's beta-amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade."J. Biol. Chem. 277:20070-20078(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Recruitment of JNK to JIP1 and JNK-dependent JIP1 phosphorylation regulates JNK module dynamics and activation."J. Biol. Chem. 278:28694-28702(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death."Diabetes 50:77-82(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Calcium- and proteasome-dependent degradation of the JNK scaffold protein islet-brain 1."J. Biol. Chem. 278:48720-48726(2003) [PubMed] [Europe PMC] [Abstract]
  9. "A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia."Nat. Med. 9:1180-1186(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Hyperphosphorylation of JNK-interacting protein 1, a protein associated with Alzheimer disease."Mol. Cell. Proteomics 5:97-113(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1."Mol. Cell. Biol. 27:7273-7283(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein."PLoS ONE 3:E1660-E1660(2008) [PubMed] [Europe PMC] [Abstract]
  13. "The gene, MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes."Nat. Genet. 24:291-295(2000) [PubMed] [Europe PMC] [Abstract]