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Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 3 (MAP3K7IP3)

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NAP1; TAB3; TGF-Beta Activated Kinase 1/MAP3K7 Binding Protein 3; TAK1 Binding Protein 3; NF-kappa-B-activating protein 1

Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 3 (MAP3K7IP3)
CCC L703
HGNC 30681
MGI 1913974
PubMed 14633987
UniProt Q8N5C8
Wiki MAP3K7IP3
MAP3K7IP3 functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.Widely expressed. Constitutively overexpressed in certain tumor tissues. Isoform 1 is a major transcript while isoform 2 is a minor transcript.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 3 (MAP3K7IP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 3 (MAP3K7IP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 3 (MAP3K7IP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 3 (MAP3K7IP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 3 (MAP3K7IP3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 3 (MAP3K7IP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 3 (MAP3K7IP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 3 (MAP3K7IP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 3 (MAP3K7IP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 3 (MAP3K7IP3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 3 (MAP3K7IP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 3 (MAP3K7IP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 3 (MAP3K7IP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 3 (MAP3K7IP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 3 (MAP3K7IP3) ELISA Kit Customized Service Offer
  1. "Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling."EMBO J. 22:6277-6288(2003) [PubMed] [Europe PMC] [Abstract]
  2. "TAB3, a new binding partner of the protein kinase TAK1."Biochem. J. 378:27-34(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of a human NF-kappaB-activating protein, TAB3."Proc. Natl. Acad. Sci. U.S.A. 101:2028-2033(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation."J. Biol. Chem. 282:16776-16782(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex."Biochem. J. 409:711-722(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-kappaB activation pathway."Cell. Mol. Life Sci. 66:2573-2584(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "TRIM5 is an innate immune sensor for the retrovirus capsid lattice."Nature 472:361-365(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]