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Mastermind Like Protein 2 (MAML2)

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MAM2; MAM-3; MAM3; MLL-MAML2

Mastermind Like Protein 2 (MAML2)
CCC L698
HGNC 16259
MGI 2389460
PubMed 23018873
RGD 1587536
UniProt Q8IZL2
Wiki MAML2
The deduced 1,153-amino acid MAML2 protein has a calculated molecular mass of 125 kD. All 3 MAML proteins contain a conserved N-terminal basic domain, but the rest of the sequences are rather divergent. In addition, all 3 are proline- and glutamine-rich, and MAML2 and MAML3 contain several glutamine stretches. Northern blot analysis detected wide expression of MAML2 and MAML3 transcripts of about 7.5 kb. Fluorescence-tagged MAML proteins were expressed in a speckled nuclear staining pattern in transfected COS-7 and osteosarcoma cells, with considerable heterogeneity in the size of the dots.The deduced protein contains 1,173 amino acids. RT-PCR ELISA detected intermediate and relatively uniform MAML2 expression in all adult and fetal tissues and specific adult brain regions examined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mastermind Like Protein 2 (MAML2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mastermind Like Protein 2 (MAML2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mastermind Like Protein 2 (MAML2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mastermind Like Protein 2 (MAML2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mastermind Like Protein 2 (MAML2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mastermind Like Protein 2 (MAML2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mastermind Like Protein 2 (MAML2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mastermind Like Protein 2 (MAML2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mastermind Like Protein 2 (MAML2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mastermind Like Protein 2 (MAML2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mastermind Like Protein 2 (MAML2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mastermind Like Protein 2 (MAML2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mastermind Like Protein 2 (MAML2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mastermind Like Protein 2 (MAML2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mastermind Like Protein 2 (MAML2) ELISA Kit Customized Service Offer
  1. "t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway."Nat. Genet. 33:208-213(2003) [PubMed] [Europe PMC] [Abstract]
  2. ErratumNat. Genet. 33:408-408(2003)
  3. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors."Exp. Cell Res. 292:21-28(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of new human mastermind proteins defines a family that consists of positive regulators for Notch signaling."J. Biol. Chem. 277:50612-50620(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors."Mol. Cell. Biol. 22:7688-7700(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)-associated TORC1-MAML2 gene fusion."Genes Chromosomes Cancer 43:202-205(2005) [PubMed] [Europe PMC] [Abstract]