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Mago Nashi Homolog, Proliferation Associated (MAGOH)

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MAGOHA; MAGOH1

Mago Nashi Homolog, Proliferation Associated (MAGOH)
CCC L696
HGNC 6815
MGI 1330312
PubMed 20364144
RGD 1305174
UniProt P61326
Wiki MAGOH
Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts.
The mammalian Mago (also known as Magoh)-Y14 heterodimer is a component of the exon junction complex. The exon junction complex is deposited on spliced mRNAs and functions in nonsense-mediated mRNA decay (NMD), a surveillance mechanism that degrades mRNAs with premature translation termination codons.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mago Nashi Homolog, Proliferation Associated (MAGOH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mago Nashi Homolog, Proliferation Associated (MAGOH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mago Nashi Homolog, Proliferation Associated (MAGOH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mago Nashi Homolog, Proliferation Associated (MAGOH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mago Nashi Homolog, Proliferation Associated (MAGOH) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mago Nashi Homolog, Proliferation Associated (MAGOH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mago Nashi Homolog, Proliferation Associated (MAGOH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mago Nashi Homolog, Proliferation Associated (MAGOH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mago Nashi Homolog, Proliferation Associated (MAGOH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mago Nashi Homolog, Proliferation Associated (MAGOH) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mago Nashi Homolog, Proliferation Associated (MAGOH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mago Nashi Homolog, Proliferation Associated (MAGOH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mago Nashi Homolog, Proliferation Associated (MAGOH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mago Nashi Homolog, Proliferation Associated (MAGOH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mago Nashi Homolog, Proliferation Associated (MAGOH) ELISA Kit Customized Service Offer
  1. "The mammalian homologue of mago nashi encodes a serum-inducible protein."Genomics 47:319-322(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "MAGOH interacts with a novel RNA-binding protein."Genomics 63:145-148(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."RNA 8:426-439(2002) [PubMed] [Europe PMC] [Abstract]
  8. "A novel mode of RBD-protein recognition in the Y14-Mago complex."Nat. Struct. Biol. 10:433-439(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex."EMBO Rep. 5:304-310(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements."Mol. Cell 20:65-75(2005) [PubMed] [Europe PMC] [Abstract]
  11. "The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity."Nat. Struct. Mol. Biol. 12:861-869(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core."RNA 11:1869-1883(2005) [PubMed] [Europe PMC] [Abstract]
  13. "PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs."Nat. Struct. Mol. Biol. 14:1173-1179(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Disassembly of exon junction complexes by PYM."Cell 137:536-548(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Assembly and mobility of exon-exon junction complexes in living cells."RNA 15:862-876(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators."Mol. Cell. Biol. 32:954-967(2012) [PubMed] [Europe PMC] [Abstract]
  18. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  19. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  20. "Structure of the Y14-Magoh core of the exon junction complex."Curr. Biol. 13:933-941(2003) [PubMed] [Europe PMC] [Abstract]
  21. "The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA."Cell 126:713-725(2006) [PubMed] [Europe PMC] [Abstract]
  22. "Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA."Science 313:1968-1972(2006) [PubMed] [Europe PMC] [Abstract]
  23. "Mechanism of ATP turnover inhibition in the EJC."RNA 15:67-75(2009) [PubMed] [Europe PMC] [Abstract]