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Membrane Associated Guanylate Kinase With Inverted Structure 2 (MAGI2)

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AIP1; ACVRIP1; ARIP1; MAGI-2; ACVRINP1; Membrane-Associated Guanylate Kinase,WW And PDZ Domain-Containing Protein 2; Atrophin-1-Interacting Protein 1

Membrane Associated Guanylate Kinase With Inverted Structure 2 (MAGI2)
CCC L695
HGNC 18957
MGI 1354953
PubMed 10681527
RGD 621855
UniProt Q86UL8
Wiki MAGI2
MAGI2 interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family.
AIP1 encodes a deduced 1,455-amino acid protein containing a guanylate kinase-like (GuK) domain, 2 WW domains, and 5 PDZ domains. AIP1 shares homology with murine MAGI1, C. elegans K01A6.1, and human AIP3/WWP3 (BAIAP1).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Membrane Associated Guanylate Kinase With Inverted Structure 2 (MAGI2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Membrane Associated Guanylate Kinase With Inverted Structure 2 (MAGI2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Membrane Associated Guanylate Kinase With Inverted Structure 2 (MAGI2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Membrane Associated Guanylate Kinase With Inverted Structure 2 (MAGI2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Membrane Associated Guanylate Kinase With Inverted Structure 2 (MAGI2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Membrane Associated Guanylate Kinase With Inverted Structure 2 (MAGI2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Membrane Associated Guanylate Kinase With Inverted Structure 2 (MAGI2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Membrane Associated Guanylate Kinase With Inverted Structure 2 (MAGI2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Membrane Associated Guanylate Kinase With Inverted Structure 2 (MAGI2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Membrane Associated Guanylate Kinase With Inverted Structure 2 (MAGI2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Membrane Associated Guanylate Kinase With Inverted Structure 2 (MAGI2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Membrane Associated Guanylate Kinase With Inverted Structure 2 (MAGI2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Membrane Associated Guanylate Kinase With Inverted Structure 2 (MAGI2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Membrane Associated Guanylate Kinase With Inverted Structure 2 (MAGI2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Membrane Associated Guanylate Kinase With Inverted Structure 2 (MAGI2) ELISA Kit Customized Service Offer
  1. "Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins."Mol. Cell. Neurosci. 11:149-160(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2."Proc. Natl. Acad. Sci. U.S.A. 97:4233-4238(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex."J. Biol. Chem. 276:48627-48630(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Postsynaptic recruitment of Dendrin depends on both dendritic mRNA transport and synaptic anchoring."J. Neurochem. 96:1659-1666(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Solution structure of the PDZ domains of human atrophin-1 interacting protein 1 (KIAA0705 protein)."Submitted (FEB-2004) to the PDB data bank