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Ly6/PLAUR Domain Containing Protein 1 (LYPD1)

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LYPDC1; PHTS; Putative HeLa tumor suppressor

Ly6/PLAUR Domain Containing Protein 1 (LYPD1)
CCC L688
HGNC 28431
MGI 1919835
PubMed 17488974
RGD 1549754
UniProt Q8N2G4
Wiki LYPD1
The deduced 141-amino acid protein has a predicted molecular mass of approximately 44 kD, confirmed by Western blot analysis. LYPD1 contains an N-terminal signal sequence and a leukocyte antigen-6 (Ly6)/uPAR (PLAUR) domain, or LU domain, characteristic of glycosylphosphatidylinositol (GPI)-linked cell surface glycoproteins and similar to the LU domain of CD59. The LYPD1 LU domain contains 12 cysteine residues potentially involved in 6 intramolecular disulfide bonds.
Upregulation of p53 (TP53) played a role in the HeLaHF cell revertant phenotype; however, RNAi-mediated downregulation of LYPD1 did not inhibit anoikis (detachment-induced apoptosis) in HeLaHF cells, in contrast to the inhibition of anoikis detected upon RNAi-mediated downregulation of p53.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ly6/PLAUR Domain Containing Protein 1 (LYPD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ly6/PLAUR Domain Containing Protein 1 (LYPD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ly6/PLAUR Domain Containing Protein 1 (LYPD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ly6/PLAUR Domain Containing Protein 1 (LYPD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ly6/PLAUR Domain Containing Protein 1 (LYPD1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ly6/PLAUR Domain Containing Protein 1 (LYPD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ly6/PLAUR Domain Containing Protein 1 (LYPD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ly6/PLAUR Domain Containing Protein 1 (LYPD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ly6/PLAUR Domain Containing Protein 1 (LYPD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ly6/PLAUR Domain Containing Protein 1 (LYPD1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ly6/PLAUR Domain Containing Protein 1 (LYPD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ly6/PLAUR Domain Containing Protein 1 (LYPD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ly6/PLAUR Domain Containing Protein 1 (LYPD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ly6/PLAUR Domain Containing Protein 1 (LYPD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ly6/PLAUR Domain Containing Protein 1 (LYPD1) ELISA Kit Customized Service Offer
  1. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]