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Lethal-3-Malignant Brain Tumor Like Protein 1 (L3MBTL1)

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L3MBTL

Lethal-3-Malignant Brain Tumor Like Protein 1 (L3MBTL1)
CCC L660
HGNC 15905
MGI 2676663
PubMed 17540172
RGD 1307316
UniProt Q9Y468
Wiki L3MBTL
L3MBTL encodes the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion mother cells in the optic centers of the brain. This gene product is localized to condensed chromosomes in mitotic cells. Overexpression of this gene in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. Alternatively spliced transcript variants encoding different isoforms have been identified.One variant, L3MBT-I, encodes a deduced 772-amino acid protein. The other, L3MBT-II, has a 118-bp insertion and encodes a deduced 738-amino acid protein that is truncated at the C terminus. Both isoforms contain 3 central mbt repeats, followed by a C2HC zinc finger and a 60-amino acid SPM domain .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lethal-3-Malignant Brain Tumor Like Protein 1 (L3MBTL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lethal-3-Malignant Brain Tumor Like Protein 1 (L3MBTL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lethal-3-Malignant Brain Tumor Like Protein 1 (L3MBTL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lethal-3-Malignant Brain Tumor Like Protein 1 (L3MBTL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lethal-3-Malignant Brain Tumor Like Protein 1 (L3MBTL1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lethal-3-Malignant Brain Tumor Like Protein 1 (L3MBTL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lethal-3-Malignant Brain Tumor Like Protein 1 (L3MBTL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lethal-3-Malignant Brain Tumor Like Protein 1 (L3MBTL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lethal-3-Malignant Brain Tumor Like Protein 1 (L3MBTL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lethal-3-Malignant Brain Tumor Like Protein 1 (L3MBTL1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lethal-3-Malignant Brain Tumor Like Protein 1 (L3MBTL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lethal-3-Malignant Brain Tumor Like Protein 1 (L3MBTL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lethal-3-Malignant Brain Tumor Like Protein 1 (L3MBTL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lethal-3-Malignant Brain Tumor Like Protein 1 (L3MBTL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lethal-3-Malignant Brain Tumor Like Protein 1 (L3MBTL1) ELISA Kit Customized Service Offer
  1. "A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes."Oncogene 18:3799-3809(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
  7. "The human L(3)MBT Polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6)."J. Biol. Chem. 278:15412-15420(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Imprinting of the human L3MBTL gene, a polycomb family member located in a region of chromosome 20 deleted in human myeloid malignancies."Proc. Natl. Acad. Sci. U.S.A. 101:7341-7346(2004) [PubMed] [Europe PMC] [Abstract]
  9. "L3MBTL1, a histone-methylation-dependent chromatin lock."Cell 129:915-928(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Histone H4 lysine 20 monomethylation promotes transcriptional repression by L3MBTL1."Oncogene 27:4293-4304(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Methylation of the retinoblastoma tumor suppressor by SMYD2."J. Biol. Chem. 285:37733-37740(2010) [PubMed] [Europe PMC] [Abstract]
  12. "The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks."Nat. Struct. Mol. Biol. 18:1345-1350(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Malignant brain tumor repeats: a three-leaved propeller architecture with ligand/peptide binding pockets."Structure 11:775-789(2003) [PubMed] [Europe PMC] [Abstract]
  14. "Structural basis for lower lysine methylation state-specific readout by MBT repeats of L3MBTL1 and an engineered PHD finger."Mol. Cell 28:677-691(2007) [PubMed] [Europe PMC] [Abstract]
  15. "L3MBTL1 recognition of mono- and dimethylated histones."Nat. Struct. Mol. Biol. 14:1229-1230(2007) [PubMed] [Europe PMC] [Abstract]
  16. ErratumNat. Struct. Mol. Biol. 15:114-114(2008)
  17. "The MBT repeats of L3MBTL1 link SET8-mediated p53 methylation at lysine 382 to target gene repression."J. Biol. Chem. 285:37725-37732(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Small molecule ligands of methyl-lysine binding proteins."Submitted (NOV-2010) to the PDB data bank