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Krev Interaction Trapped Protein 1 (KRIT1)

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CAM; CCM1; Cerebral Cavernous Malformations 1

Krev Interaction Trapped Protein 1 (KRIT1)
CCC L658
HGNC 1573
MGI 1930618
PubMed 24291398
RGD 1305929
UniProt O00522
Wiki KRIT1
KRIT1 encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Krev Interaction Trapped Protein 1 (KRIT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Krev Interaction Trapped Protein 1 (KRIT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Krev Interaction Trapped Protein 1 (KRIT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Krev Interaction Trapped Protein 1 (KRIT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Krev Interaction Trapped Protein 1 (KRIT1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Krev Interaction Trapped Protein 1 (KRIT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Krev Interaction Trapped Protein 1 (KRIT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Krev Interaction Trapped Protein 1 (KRIT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Krev Interaction Trapped Protein 1 (KRIT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Krev Interaction Trapped Protein 1 (KRIT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Krev Interaction Trapped Protein 1 (KRIT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Krev Interaction Trapped Protein 1 (KRIT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Krev Interaction Trapped Protein 1 (KRIT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Krev Interaction Trapped Protein 1 (KRIT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Krev Interaction Trapped Protein 1 (KRIT1) ELISA Kit Customized Service Offer
  1. "Association of Krev-1/rap1a with Krit1, a novel ankyrin repeat-containing protein encoded by a gene mapping to 7q21-22."Oncogene 15:1043-1049(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning of the murine Krit1 cDNA reveals novel mammalian 5' coding exons."Genomics 70:392-395(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Computational and experimental analyses reveal previously undetected coding exons of the KRIT1 (CCM1) gene."Genomics 71:123-126(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Mutation and expression analysis of the KRIT1 gene associated with cerebral cavernous malformations (CCM1)."Acta Neuropathol. 104:231-240(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of eight novel 5`-exons in cerebral capillary malformation gene-1 (CCM1) encoding KRIT1."Biochim. Biophys. Acta 1517:464-467(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Interaction between krit1 and icap1alpha infers perturbation of integrin beta1-mediated angiogenesis in the pathogenesis of cerebral cavernous malformation."Hum. Mol. Genet. 10:2953-2960(2001) [PubMed] [Europe PMC] [Abstract]
  10. "KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis."Hum. Mol. Genet. 11:389-396(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Krit 1 interactions with microtubules and membranes are regulated by Rap1 and integrin cytoplasmic domain associated protein-1."FEBS J. 274:5518-5532(2007) [PubMed] [Europe PMC] [Abstract]
  12. "CCM1 regulates vascular-lumen organization by inducing endothelial polarity."J. Cell Sci. 123:1073-1080(2010) [PubMed] [Europe PMC] [Abstract]
  13. "KRIT1 regulates the homeostasis of intracellular reactive oxygen species."PLoS ONE 5:E11786-E11786(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling."Proc. Natl. Acad. Sci. U.S.A. 107:12640-12645(2010) [PubMed] [Europe PMC] [Abstract]
  15. "A mechanism of Rap1-induced stabilization of endothelial cell--cell junctions."Mol. Biol. Cell 22:2509-2519(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Structural basis for small G protein effector interaction of Ras-related protein 1 (Rap1) and adaptor protein Krev interaction trapped 1 (KRIT1)."J. Biol. Chem. 287:22317-22327(2012) [PubMed] [Europe PMC] [Abstract]
  17. "Structural basis of the junctional anchorage of the cerebral cavernous malformations complex."J. Cell Biol. 199:39-48(2012) [PubMed] [Europe PMC] [Abstract]
  18. "Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation."Mol. Cell 0:0-0(2013)