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Integrin Beta 1 Binding Protein 1 (ITGb1BP1)

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ICAP-1A; ICAP-1B; ICAP1; ICAP1A; ICAP1B; Integrin Cytoplasmic Domain-Associated Protein 1; Bodenin

Integrin Beta 1 Binding Protein 1 (ITGb1BP1)
CCC L631
HGNC 23927
MGI 1306802
PubMed 11854171
RGD 1307810
UniProt O14713
Wiki ITGB1BP1
The cytoplasmic domains of integrins are essential for cell adhesion. ITGB1BP1 binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion.The authors hypothesized that KRIT1 may be involved in bidirectional signaling between integrin molecules and the cytoskeleton, and that KRIT1 may affect cell adhesion processes via integrin signaling in CCM1 pathogenesis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Integrin Beta 1 Binding Protein 1 (ITGb1BP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Integrin Beta 1 Binding Protein 1 (ITGb1BP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Integrin Beta 1 Binding Protein 1 (ITGb1BP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Integrin Beta 1 Binding Protein 1 (ITGb1BP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrin Beta 1 Binding Protein 1 (ITGb1BP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Integrin Beta 1 Binding Protein 1 (ITGb1BP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Integrin Beta 1 Binding Protein 1 (ITGb1BP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Integrin Beta 1 Binding Protein 1 (ITGb1BP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Integrin Beta 1 Binding Protein 1 (ITGb1BP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrin Beta 1 Binding Protein 1 (ITGb1BP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Integrin Beta 1 Binding Protein 1 (ITGb1BP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Integrin Beta 1 Binding Protein 1 (ITGb1BP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Integrin Beta 1 Binding Protein 1 (ITGb1BP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Integrin Beta 1 Binding Protein 1 (ITGb1BP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrin Beta 1 Binding Protein 1 (ITGb1BP1) ELISA Kit Customized Service Offer
  1. "ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin."J. Cell Biol. 138:1149-1157(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Interaction of the integrin beta1 cytoplasmic domain with ICAP-1 protein."J. Biol. Chem. 274:11-19(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Calcium/calmodulin-dependent protein kinase II controls integrin alpha5beta1-mediated cell adhesion through the integrin cytoplasmic domain associated protein-1alpha."Biochem. Biophys. Res. Commun. 252:46-50(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Interaction between krit1 and icap1alpha infers perturbation of integrin beta1-mediated angiogenesis in the pathogenesis of cerebral cavernous malformation."Hum. Mol. Genet. 10:2953-2960(2001) [PubMed] [Europe PMC] [Abstract]
  7. "KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis."Hum. Mol. Genet. 11:389-396(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Molecular basis for interaction between Icap1alpha PTB domain and beta 1 integrin."J. Biol. Chem. 277:8140-8145(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement."J. Biol. Chem. 277:20895-20902(2002) [PubMed] [Europe PMC] [Abstract]
  10. "The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading."J. Cell Biol. 156:377-387(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Disruption of focal adhesions by integrin cytoplasmic domain-associated protein-1 alpha."J. Biol. Chem. 278:6567-6574(2003) [PubMed] [Europe PMC] [Abstract]
  12. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Nuclear translocation of integrin cytoplasmic domain-associated protein 1 stimulates cellular proliferation."Mol. Biol. Cell 16:1859-1871(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Krit 1 interactions with microtubules and membranes are regulated by Rap1 and integrin cytoplasmic domain associated protein-1."FEBS J. 274:5518-5532(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis."Circ. Res. 107:592-601(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Osteoblast mineralization requires beta1 integrin/ICAP-1-dependent fibronectin deposition."J. Cell Biol. 194:307-322(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation."Mol. Cell 0:0-0(2013)