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InaD Like Protein (INADL)

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Cipp; PATJ; Pals1-associated tight junction protein; Protein associated to tight junctions

InaD Like Protein (INADL)
CCC L623
HGNC 28881
MGI 1277960
PubMed 9280290
RGD 1565362
UniProt Q8NI35
Wiki INADL
INADL encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors.
A 75-kD protein was present in both membrane and cytosolic fractions of Caco-2 cells. Immunoelectron microscopy localized INDAL near tight junctions in human colon and Caco-2 cells, often on the apical side, and also beneath the apical plasma membrane and in microvilli.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant InaD Like Protein (INADL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to InaD Like Protein (INADL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to InaD Like Protein (INADL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for InaD Like Protein (INADL) CLIA Kit Customized Service Offer
n/a ELISA Kit for InaD Like Protein (INADL) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant InaD Like Protein (INADL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to InaD Like Protein (INADL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to InaD Like Protein (INADL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for InaD Like Protein (INADL) CLIA Kit Customized Service Offer
n/a ELISA Kit for InaD Like Protein (INADL) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant InaD Like Protein (INADL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to InaD Like Protein (INADL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to InaD Like Protein (INADL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for InaD Like Protein (INADL) CLIA Kit Customized Service Offer
n/a ELISA Kit for InaD Like Protein (INADL) ELISA Kit Customized Service Offer
  1. "Molecular characterization of a novel PDZ domain protein with homology to INAD from Drosophila melanogaster."FEBS Lett. 413:243-248(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation of novel heart-specific genes using the BodyMap database."Genomics 74:115-120(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost."J. Cell Biol. 157:161-172(2002) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells."J. Biol. Chem. 277:25408-25415(2002) [PubMed] [Europe PMC] [Abstract]
  7. "The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions."J. Biol. Chem. 277:27501-27509(2002) [PubMed] [Europe PMC] [Abstract]
  8. "A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells."Cell 125:535-548(2006) [PubMed] [Europe PMC] [Abstract]
  9. "KIBRA modulates directional migration of podocytes."J. Am. Soc. Nephrol. 19:1891-1903(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Structural basis for L27 domain-mediated assembly of signaling and cell polarity complexes."EMBO J. 23:2723-2733(2004) [PubMed] [Europe PMC] [Abstract]
  17. "Solution structure of PDZ domains of INAD-like protein."Submitted (OCT-2006) to the PDB data bank