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IKAROS Family Zinc Finger Protein 3 (IKZF3)

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AIOLOS; ZNFN1A3; Zinc finger protein Aiolos

IKAROS Family Zinc Finger Protein 3 (IKZF3)
CCC L619
HGNC 13178
MGI 1342542
PubMed 22464253
RGD 1307024
UniProt Q9UKT9
Wiki IKZF3
IKZF3 encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling.
Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant IKAROS Family Zinc Finger Protein 3 (IKZF3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to IKAROS Family Zinc Finger Protein 3 (IKZF3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to IKAROS Family Zinc Finger Protein 3 (IKZF3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for IKAROS Family Zinc Finger Protein 3 (IKZF3) CLIA Kit Customized Service Offer
n/a ELISA Kit for IKAROS Family Zinc Finger Protein 3 (IKZF3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant IKAROS Family Zinc Finger Protein 3 (IKZF3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to IKAROS Family Zinc Finger Protein 3 (IKZF3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to IKAROS Family Zinc Finger Protein 3 (IKZF3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for IKAROS Family Zinc Finger Protein 3 (IKZF3) CLIA Kit Customized Service Offer
n/a ELISA Kit for IKAROS Family Zinc Finger Protein 3 (IKZF3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant IKAROS Family Zinc Finger Protein 3 (IKZF3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to IKAROS Family Zinc Finger Protein 3 (IKZF3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to IKAROS Family Zinc Finger Protein 3 (IKZF3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for IKAROS Family Zinc Finger Protein 3 (IKZF3) CLIA Kit Customized Service Offer
n/a ELISA Kit for IKAROS Family Zinc Finger Protein 3 (IKZF3) ELISA Kit Customized Service Offer
  1. "Human aiolos, an ikaros-related zinc finger DNA binding protein: cDNA cloning, tissue expression pattern, and chromosomal mapping."Genomics 61:326-329(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Both normal and leukemic B lymphocytes express multiple isoforms of the human Aiolos gene."Eur. J. Immunol. 31:3469-3474(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Combinatorial effects of splice variants modulate function of Aiolos."J. Cell Sci. 120:2619-2630(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization."EMBO J. 18:3419-3430(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities."J. Biol. Chem. 275:38347-38354(2000) [PubMed] [Europe PMC] [Abstract]
  9. "The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis."J. Immunol. 167:6366-6373(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells."Nat. Immunol. 11:846-853(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma." Nature 469:539-542(2011) [PubMed] [Europe PMC] [Abstract]