Intraflagellar Transport Protein 74 (IFT74)
[Edit]CMG1; CCDC2; Coiled-Coil Domain-Containing Protein 2; Capillary Morphogenesis Gene 1 Protein
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CMG1 was 1 of several transcripts upregulated by umbilical vein endothelial cells during capillary morphogenesis in 3-dimensional collagen matrices.deduced 600-amino acid protein has a calculated molecular mass of 65 kD. CMG1 contains a coiled-coil domain and several putative phosphorylation sites. The coiled-coil domain shares 24% identity with myosin heavy chain sequences from various species. RT-PCR detected highest expression in adult and fetal kidney and lower expression in adult heart, placenta, lung, liver, and pancreas, and in fetal heart, lung, and liver. Little to no expression was detected in adult brain and skeletal muscle or in fetal brain, thymus, and spleen. Transfection into epithelial tumor cells revealed targeting of fluorescent-tagged CMG1 to an intracellular vesicular compartment.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Intraflagellar Transport Protein 74 (IFT74) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Intraflagellar Transport Protein 74 (IFT74) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Intraflagellar Transport Protein 74 (IFT74) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Intraflagellar Transport Protein 74 (IFT74) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Intraflagellar Transport Protein 74 (IFT74) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Intraflagellar Transport Protein 74 (IFT74) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Intraflagellar Transport Protein 74 (IFT74) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Intraflagellar Transport Protein 74 (IFT74) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Intraflagellar Transport Protein 74 (IFT74) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Intraflagellar Transport Protein 74 (IFT74) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Intraflagellar Transport Protein 74 (IFT74) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Intraflagellar Transport Protein 74 (IFT74) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Intraflagellar Transport Protein 74 (IFT74) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Intraflagellar Transport Protein 74 (IFT74) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Intraflagellar Transport Protein 74 (IFT74) | ELISA Kit Customized Service Offer |
- "Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling."J. Cell Sci. 114:2755-2773(2001) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Primary cilia of human endothelial cells disassemble under laminar shear stress."J. Cell Biol. 164:811-817(2004) [PubMed] [Europe PMC] [Abstract]
- "Characterization of the intraflagellar transport complex B core: direct interaction of the IFT81 and IFT74/72 subunits."J. Biol. Chem. 280:27688-27696(2005) [PubMed] [Europe PMC] [Abstract]
- "Active transport and diffusion barriers restrict Joubert syndrome-associated ARL13B/ARL-13 to an inv-like ciliary membrane subdomain." PLoS Genet. 9:E1003977-E1003977(2013) [PubMed] [Europe PMC] [Abstract]
- "Molecular basis of tubulin transport within the cilium by IFT74 and IFT81."Science 341:1009-1012(2013) [PubMed] [Europe PMC] [Abstract]