Hermansky Pudlak Syndrome Protein 5 (HPS5)

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AIBP63; Ru2; Alpha-integrin-binding protein 63; Ruby-eye protein 2 homolog

Hermansky Pudlak Syndrome Protein 5 (HPS5)
HPS5 encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. This protein interacts with Hermansky-Pudlak syndrome 6 protein and may interact with the cytoplasmic domain of integrin, alpha-3. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 5. Multiple transcript variants encoding two distinct isoforms have been identified for this gene.The predicted partial HPS5 sequence contains numerous putative phosphorylation sites for protein kinase A, protein kinase C, and casein kinase II, as well as a putative myristoylation site. HPS5 bound all alpha-integrin chains that had an aromatic amino acid before the first lysine of the conserved KXGFFKR motif, including alpha-2, alpha-3, alpha-3B, alpha-5, and alpha-6A.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hermansky Pudlak Syndrome Protein 5 (HPS5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hermansky Pudlak Syndrome Protein 5 (HPS5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hermansky Pudlak Syndrome Protein 5 (HPS5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hermansky Pudlak Syndrome Protein 5 (HPS5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hermansky Pudlak Syndrome Protein 5 (HPS5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hermansky Pudlak Syndrome Protein 5 (HPS5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hermansky Pudlak Syndrome Protein 5 (HPS5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hermansky Pudlak Syndrome Protein 5 (HPS5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hermansky Pudlak Syndrome Protein 5 (HPS5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hermansky Pudlak Syndrome Protein 5 (HPS5) ELISA Kit Customized Service Offer
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  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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  7. "Characterization of BLOC-2, a complex containing the Hermansky-Pudlak syndrome proteins HPS3, HPS5 and HPS6."Traffic 5:276-283(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Improper trafficking of melanocyte-specific proteins in Hermansky-Pudlak syndrome type-5."J. Invest. Dermatol. 127:1471-1478(2007) [PubMed] [Europe PMC] [Abstract]
  9. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Cellular, molecular and clinical characterization of patients with Hermansky-Pudlak syndrome type 5."Traffic 5:711-722(2004) [PubMed] [Europe PMC] [Abstract]