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Homocysteine Inducible, Endoplasmic Reticulum Stress Inducible, Ubiquitin Like Domain Member 1 (HERPUD1)

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HERP; Mif1; SUP; Methyl methanesulfonate (MMF)-inducible fragment protein 1

Homocysteine Inducible, Endoplasmic Reticulum Stress Inducible, Ubiquitin Like Domain Member 1 (HERPUD1)
CCC L579
HGNC 13744
MGI 1927406
PubMed 16707422
RGD 620818
UniProt Q15011
Wiki HERPUD1
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. HERPUD1 may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system.
This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. The full-length nature of all transcript variants has not been determined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Homocysteine Inducible, Endoplasmic Reticulum Stress Inducible, Ubiquitin Like Domain Member 1 (HERPUD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Homocysteine Inducible, Endoplasmic Reticulum Stress Inducible, Ubiquitin Like Domain Member 1 (HERPUD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Homocysteine Inducible, Endoplasmic Reticulum Stress Inducible, Ubiquitin Like Domain Member 1 (HERPUD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Homocysteine Inducible, Endoplasmic Reticulum Stress Inducible, Ubiquitin Like Domain Member 1 (HERPUD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Homocysteine Inducible, Endoplasmic Reticulum Stress Inducible, Ubiquitin Like Domain Member 1 (HERPUD1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Homocysteine Inducible, Endoplasmic Reticulum Stress Inducible, Ubiquitin Like Domain Member 1 (HERPUD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Homocysteine Inducible, Endoplasmic Reticulum Stress Inducible, Ubiquitin Like Domain Member 1 (HERPUD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Homocysteine Inducible, Endoplasmic Reticulum Stress Inducible, Ubiquitin Like Domain Member 1 (HERPUD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Homocysteine Inducible, Endoplasmic Reticulum Stress Inducible, Ubiquitin Like Domain Member 1 (HERPUD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Homocysteine Inducible, Endoplasmic Reticulum Stress Inducible, Ubiquitin Like Domain Member 1 (HERPUD1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Homocysteine Inducible, Endoplasmic Reticulum Stress Inducible, Ubiquitin Like Domain Member 1 (HERPUD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Homocysteine Inducible, Endoplasmic Reticulum Stress Inducible, Ubiquitin Like Domain Member 1 (HERPUD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Homocysteine Inducible, Endoplasmic Reticulum Stress Inducible, Ubiquitin Like Domain Member 1 (HERPUD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Homocysteine Inducible, Endoplasmic Reticulum Stress Inducible, Ubiquitin Like Domain Member 1 (HERPUD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Homocysteine Inducible, Endoplasmic Reticulum Stress Inducible, Ubiquitin Like Domain Member 1 (HERPUD1) ELISA Kit Customized Service Offer
  1. "Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress."J. Biol. Chem. 275:32846-32853(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of ERSE-II, a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein response."J. Biol. Chem. 276:9199-9205(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein."J. Biol. Chem. 277:12915-12920(2002) [PubMed] [Europe PMC] [Abstract]
  7. "The novel MMS-inducible gene Mif1/KIAA0025 is a target of the unfolded protein response pathway."FEBS Lett. 469:123-131(2000) [PubMed] [Europe PMC] [Abstract]
  8. "The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway."J. Mol. Biol. 354:1021-1027(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element."Mol. Cell. Biol. 26:7999-8010(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Ubxd1 is a novel co-factor of the human p97 ATPase."Int. J. Biochem. Cell Biol. 40:2927-2942(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Solution structure of the UBL-domain of HERP."Submitted (NOV-2004) to the PDB data bank