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G1-To-S-Phase Transition 1 (GSPT1)

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ETF3A; GST1; eRF3a; Eukaryotic peptide chain release factor subunit 3a

G1-To-S-Phase Transition 1 (GSPT1)
CCC L571
HGNC 4621
MGI 1316728
PubMed 17700517
RGD 2751
UniProt P15170
Wiki GSPT1
GST1, seemed to be essential for the G1- to S-phase transition in the yeast cell cycle. The gene product appeared to be a GTP-binding protein of molecular mass 76,565 Da with 38% identity in amino acid sequence with the alpha subunit of elongation factor-1.
The deduced 635-amino acid protein has a unique N terminus and a conserved C-terminal eukaryotic elongation factor-1-alpha-like domain. The mouse and human Gspt1 proteins share 94% sequence identity. RT-PCR analysis indicated expression of Gspt1 in all mouse tissues examined.GSPT1 bound the p19(ARF) isoform of CDKN2A, but not the p16(INK4A) isoform.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G1-To-S-Phase Transition 1 (GSPT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G1-To-S-Phase Transition 1 (GSPT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G1-To-S-Phase Transition 1 (GSPT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G1-To-S-Phase Transition 1 (GSPT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for G1-To-S-Phase Transition 1 (GSPT1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G1-To-S-Phase Transition 1 (GSPT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G1-To-S-Phase Transition 1 (GSPT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G1-To-S-Phase Transition 1 (GSPT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G1-To-S-Phase Transition 1 (GSPT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for G1-To-S-Phase Transition 1 (GSPT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G1-To-S-Phase Transition 1 (GSPT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G1-To-S-Phase Transition 1 (GSPT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G1-To-S-Phase Transition 1 (GSPT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G1-To-S-Phase Transition 1 (GSPT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for G1-To-S-Phase Transition 1 (GSPT1) ELISA Kit Customized Service Offer
  1. "A human homologue of the yeast GST1 gene codes for a GTP-binding protein and is expressed in a proliferation-dependent manner in mammalian cells."EMBO J. 8:3807-3814(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q."Genomics 60:295-308(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay."Genes Dev. 23:1091-1105(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Molecular basis of eRF3 recognition by the MLLE domain of poly(A)-binding protein."PLoS ONE 5:E10169-E10169(2010) [PubMed] [Europe PMC] [Abstract]