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Transmembrane Glycoprotein NMB (GPNMB)

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NMB; HGFIN; Glycoprotein NMB-Like Protein; Osteoactivin

Transmembrane Glycoprotein NMB (GPNMB)
CCC L566
HGNC 4462
MGI 1934765
PubMed 20711474
RGD 71008
UniProt Q14956
Wiki GPNMB
GPNMB is a type I transmembrane glycoprotein which shows homology to the pmel17 precursor, a melanocyte-specific protein.GPNMB has been reported to be expressed in various cell types, including: melanocytes, osteoclasts, osteoblasts, dendritic cells, and it is overexpressed in various cancer types. In melanocytic cells and osteoclasts the GPNMB gene is transcritionally regulated by Microphthalmia-associated transcription factor. In osteoblast progenitor cells, Osteoactivin is induced by BMP-2 in a SMAD1 dependent manner to promote osteoblast differentiation. Similarly, Osteoactivin expression increases during osteoclast differentiation and it is functionally implicated in this process, possibly by promoting the fusion of osteoclast progenitor cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Glycoprotein NMB (GPNMB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Glycoprotein NMB (GPNMB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Glycoprotein NMB (GPNMB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transmembrane Glycoprotein NMB (GPNMB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transmembrane Glycoprotein NMB (GPNMB) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Glycoprotein NMB (GPNMB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Glycoprotein NMB (GPNMB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Glycoprotein NMB (GPNMB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transmembrane Glycoprotein NMB (GPNMB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transmembrane Glycoprotein NMB (GPNMB) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Glycoprotein NMB (GPNMB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Glycoprotein NMB (GPNMB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Glycoprotein NMB (GPNMB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transmembrane Glycoprotein NMB (GPNMB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transmembrane Glycoprotein NMB (GPNMB) ELISA Kit Customized Service Offer
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  10. "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  12. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]