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Glycerol-3-Phosphate Dehydrogenase-1-Like Protein (GPD1L)

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Glycerol-3-Phosphate Dehydrogenase-1-Like Protein (GPD1L)
CCC L565
HGNC 28956
MGI 1289257
PubMed 18762705
RGD 1560123
UniProt Q8N335
Wiki GPD1L
GPD1L catalyzes the conversion of sn-glycerol 3-phosphate to glycerone phosphate. The encoded protein is found in the cytoplasm, associated with the plasma membrane, where it binds the sodium channel, voltage-gated, type V, alpha subunit (SCN5A). Defects in this gene are a cause of Brugada syndrome type 2 (BRS2) as well as sudden infant death syndrome (SIDS).
The deduced 411-amino acid protein contains an NAD-dependent glycerol-3-phosphate dehydrogenase (GPD1) motif, and it shares 71.8% identity with GPD1. Northern blot analysis detected a single GPD1L transcript in all tissues examined except liver. Highest expression was in heart and skeletal muscle.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glycerol-3-Phosphate Dehydrogenase-1-Like Protein (GPD1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glycerol-3-Phosphate Dehydrogenase-1-Like Protein (GPD1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glycerol-3-Phosphate Dehydrogenase-1-Like Protein (GPD1L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glycerol-3-Phosphate Dehydrogenase-1-Like Protein (GPD1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glycerol-3-Phosphate Dehydrogenase-1-Like Protein (GPD1L) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glycerol-3-Phosphate Dehydrogenase-1-Like Protein (GPD1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glycerol-3-Phosphate Dehydrogenase-1-Like Protein (GPD1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glycerol-3-Phosphate Dehydrogenase-1-Like Protein (GPD1L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glycerol-3-Phosphate Dehydrogenase-1-Like Protein (GPD1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glycerol-3-Phosphate Dehydrogenase-1-Like Protein (GPD1L) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glycerol-3-Phosphate Dehydrogenase-1-Like Protein (GPD1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glycerol-3-Phosphate Dehydrogenase-1-Like Protein (GPD1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glycerol-3-Phosphate Dehydrogenase-1-Like Protein (GPD1L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glycerol-3-Phosphate Dehydrogenase-1-Like Protein (GPD1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glycerol-3-Phosphate Dehydrogenase-1-Like Protein (GPD1L) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."DNA Res. 2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "GPD1L links redox state to cardiac excitability by PKC-dependent phosphorylation of the sodium channel SCN5A."Am. J. Physiol. 297:H1446-H1452(2009) [PubMed] [Europe PMC] [Abstract]
  5. "Cardiac Na+ current regulation by pyridine nucleotides."Circ. Res. 105:737-745(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Crystal structure of human glycerol-3-phosphate dehydrogenase 1-like protein."Submitted (MAY-2007) to the PDB data bank
  8. "Molecular and functional characterization of novel glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) mutations in sudden infant death syndrome."Circulation 116:2253-2259(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Mutation in glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmias."Circulation 116:2260-2268(2007) [PubMed] [Europe PMC] [Abstract]