GINS Complex Subunit 2 (GINS2)

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PSF2; DC5; DNA replication complex GINS protein PSF2

GINS Complex Subunit 2 (GINS2)
The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4), Psf1 (GINS1), Psf2, and Psf3 (GINS3). The formation of this complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts.By searching a human database for sequences similar to yeast Psf2, Takayama et al. (2003) identified GINS2, which they called PSF2. The deduced protein contains 185 amino acids.
The International Radiation Hybrid Mapping Consortium mapped the GINS2 gene to chromosome 16.The GINS complex derives its name from the Japanese words Go, Ichi, Nii, and San, which mean 5, 1, 2, and 3, respectively, and refer to the numbering of the yeast homologs of the GINS complex.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GINS Complex Subunit 2 (GINS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GINS Complex Subunit 2 (GINS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GINS Complex Subunit 2 (GINS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GINS Complex Subunit 2 (GINS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for GINS Complex Subunit 2 (GINS2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GINS Complex Subunit 2 (GINS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GINS Complex Subunit 2 (GINS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GINS Complex Subunit 2 (GINS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GINS Complex Subunit 2 (GINS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for GINS Complex Subunit 2 (GINS2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GINS Complex Subunit 2 (GINS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GINS Complex Subunit 2 (GINS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GINS Complex Subunit 2 (GINS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GINS Complex Subunit 2 (GINS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for GINS Complex Subunit 2 (GINS2) ELISA Kit Customized Service Offer
  1. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Molecular architecture of the human GINS complex."EMBO Rep. 8:678-684(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structure of the human GINS complex."Genes Dev. 21:1316-1321(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Structure of the human GINS complex and its assembly and functional interface in replication initiation."Nat. Struct. Mol. Biol. 14:388-396(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Crystal structure of the GINS complex and functional insights into its role in DNA replication."Proc. Natl. Acad. Sci. U.S.A. 104:12685-12690(2007) [PubMed] [Europe PMC] [Abstract]