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GINS Complex Subunit 1 (GINS1)

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PSF1; DNA replication complex GINS protein PSF1

GINS Complex Subunit 1 (GINS1)
CCC L556
HGNC 28980
MGI 1916520
PubMed 8724849
RGD 1562246
UniProt Q14691
Wiki GINS1
The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4), Psf1, Psf2 (GINS2), and Psf3 (GINS3). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts.
The 3-prime UTR contains a complex array of Alu repeats and partial LINE sequences, and the deduced protein contains 196 amino acids. Northern blot analysis detected moderate expression in thymus, testis, KG-1 cells, and HeLa cells, with low expression in small intestine and colon, and no expression in the other tissues examined.Without GINS, neither Dpb11, which is a homolog of TOPBP1, nor Cdc45 associated properly with chromatin DNA. Without Dpb11 and Sld3, GINS did not associate with replication origins. Genetic and 2-hybrid analysis suggested that GINS interacted with Sld3 and Dpb11.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GINS Complex Subunit 1 (GINS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GINS Complex Subunit 1 (GINS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GINS Complex Subunit 1 (GINS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GINS Complex Subunit 1 (GINS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for GINS Complex Subunit 1 (GINS1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GINS Complex Subunit 1 (GINS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GINS Complex Subunit 1 (GINS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GINS Complex Subunit 1 (GINS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GINS Complex Subunit 1 (GINS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for GINS Complex Subunit 1 (GINS1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GINS Complex Subunit 1 (GINS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GINS Complex Subunit 1 (GINS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GINS Complex Subunit 1 (GINS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GINS Complex Subunit 1 (GINS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for GINS Complex Subunit 1 (GINS1) ELISA Kit Customized Service Offer
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  7. "Molecular architecture of the human GINS complex."EMBO Rep. 8:678-684(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Crystal structure of the human GINS complex."Genes Dev. 21:1316-1321(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Structure of the human GINS complex and its assembly and functional interface in replication initiation."Nat. Struct. Mol. Biol. 14:388-396(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Crystal structure of the GINS complex and functional insights into its role in DNA replication."Proc. Natl. Acad. Sci. U.S.A. 104:12685-12690(2007) [PubMed] [Europe PMC] [Abstract]