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Golgi Associated Gamma Adaptin Ear Containing ARF Binding Protein 3 (GgA3)

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ADP-ribosylation factor-binding protein GGA3

Golgi Associated Gamma Adaptin Ear Containing ARF Binding Protein 3 (GgA3)
CCC L551
HGNC 17079
MGI 2384159
PubMed 22836275
RGD 1309553
UniProt Q9NZ52
Wiki GGA3
GGA3 encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. As GGA3 was removed by caspase cleavage, BACE was stabilized, leading to elevated beta-secretase cleavage of APP. Silencing of GGA3 by RNA interference led to increased levels of BACE and the APP cleavage products C99 and A-beta. GGA3 protein levels were significantly decreased and were inversely correlated with BACE levels in AD brains, but not in nondemented control brains.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Golgi Associated Gamma Adaptin Ear Containing ARF Binding Protein 3 (GgA3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Golgi Associated Gamma Adaptin Ear Containing ARF Binding Protein 3 (GgA3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Golgi Associated Gamma Adaptin Ear Containing ARF Binding Protein 3 (GgA3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Golgi Associated Gamma Adaptin Ear Containing ARF Binding Protein 3 (GgA3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Golgi Associated Gamma Adaptin Ear Containing ARF Binding Protein 3 (GgA3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Golgi Associated Gamma Adaptin Ear Containing ARF Binding Protein 3 (GgA3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Golgi Associated Gamma Adaptin Ear Containing ARF Binding Protein 3 (GgA3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Golgi Associated Gamma Adaptin Ear Containing ARF Binding Protein 3 (GgA3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Golgi Associated Gamma Adaptin Ear Containing ARF Binding Protein 3 (GgA3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Golgi Associated Gamma Adaptin Ear Containing ARF Binding Protein 3 (GgA3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Golgi Associated Gamma Adaptin Ear Containing ARF Binding Protein 3 (GgA3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Golgi Associated Gamma Adaptin Ear Containing ARF Binding Protein 3 (GgA3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Golgi Associated Gamma Adaptin Ear Containing ARF Binding Protein 3 (GgA3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Golgi Associated Gamma Adaptin Ear Containing ARF Binding Protein 3 (GgA3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Golgi Associated Gamma Adaptin Ear Containing ARF Binding Protein 3 (GgA3) ELISA Kit Customized Service Offer
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  8. "The GGAs promote ARF-dependent recruitment of clathrin to the TGN."Cell 105:93-102(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Sorting of mannose 6-phosphate receptors mediated by the GGAs."Science 292:1712-1716(2001) [PubMed] [Europe PMC] [Abstract]
  10. "GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors."Biochem. J. 365:369-378(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics."J. Cell Biol. 158:855-862(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Autoinhibition of the ligand-binding site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif."Proc. Natl. Acad. Sci. U.S.A. 99:8072-8077(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins."Biochemistry 42:12174-12180(2003) [PubMed] [Europe PMC] [Abstract]
  14. "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex."EMBO J. 22:78-88(2003) [PubMed] [Europe PMC] [Abstract]
  15. "Mammalian GGAs act together to sort mannose 6-phosphate receptors."J. Cell Biol. 163:755-766(2003) [PubMed] [Europe PMC] [Abstract]
  16. "GAT (GGA and Tom1) domain responsible for ubiquitin binding and ubiquitination."J. Biol. Chem. 279:7105-7111(2004) [PubMed] [Europe PMC] [Abstract]
  17. "Definition of the consensus motif recognized by gamma-adaptin ear domains."J. Biol. Chem. 279:8018-8028(2004) [PubMed] [Europe PMC] [Abstract]
  18. "The trihelical bundle subdomain of the GGA proteins interacts with multiple partners through overlapping but distinct sites."J. Biol. Chem. 279:31409-31418(2004) [PubMed] [Europe PMC] [Abstract]
  19. "Interactions of GGA3 with the ubiquitin sorting machinery."Nat. Cell Biol. 6:244-251(2004) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  22. "Phosphoregulation of sorting signal-VHS domain interactions by a direct electrostatic mechanism."Nat. Struct. Biol. 9:532-536(2002) [PubMed] [Europe PMC] [Abstract]
  23. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]