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Golgi Associated Gamma Adaptin Ear Containing ARF Binding Protein 2 (GgA2)

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VEAR; Gamma-adaptin-related protein 2; VHS domain and ear domain of gamma-adaptin; ADP-ribosylation factor-binding protein GGA2

Golgi Associated Gamma Adaptin Ear Containing ARF Binding Protein 2 (GgA2)
CCC L550
HGNC 16064
MGI 1921355
PubMed 22291915
RGD 1304800
UniProt Q9UJY4
Wiki GGA2
GGA2 encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly.Receptors with mutations in this motif were defective in lysosomal enzyme sorting. The hinge domain of GGA2 bound clathrin, suggesting that GGA2 could be a link between cargo molecules and clathrin-coated vesicle assembly.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Golgi Associated Gamma Adaptin Ear Containing ARF Binding Protein 2 (GgA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Golgi Associated Gamma Adaptin Ear Containing ARF Binding Protein 2 (GgA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Golgi Associated Gamma Adaptin Ear Containing ARF Binding Protein 2 (GgA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Golgi Associated Gamma Adaptin Ear Containing ARF Binding Protein 2 (GgA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Golgi Associated Gamma Adaptin Ear Containing ARF Binding Protein 2 (GgA2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Golgi Associated Gamma Adaptin Ear Containing ARF Binding Protein 2 (GgA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Golgi Associated Gamma Adaptin Ear Containing ARF Binding Protein 2 (GgA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Golgi Associated Gamma Adaptin Ear Containing ARF Binding Protein 2 (GgA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Golgi Associated Gamma Adaptin Ear Containing ARF Binding Protein 2 (GgA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Golgi Associated Gamma Adaptin Ear Containing ARF Binding Protein 2 (GgA2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Golgi Associated Gamma Adaptin Ear Containing ARF Binding Protein 2 (GgA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Golgi Associated Gamma Adaptin Ear Containing ARF Binding Protein 2 (GgA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Golgi Associated Gamma Adaptin Ear Containing ARF Binding Protein 2 (GgA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Golgi Associated Gamma Adaptin Ear Containing ARF Binding Protein 2 (GgA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Golgi Associated Gamma Adaptin Ear Containing ARF Binding Protein 2 (GgA2) ELISA Kit Customized Service Offer
  1. "A family of ADP-ribosylation factor effectors that can alter transport through the trans-Golgi."Mol. Biol. Cell 11:1241-1255(2000) [PubMed] [Europe PMC] [Abstract]
  2. "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome."J. Cell Biol. 149:67-80(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Vear, a novel Golgi-associated protein with VHS and gamma-adaptin 'ear' domains."J. Biol. Chem. 275:7176-7183(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q."Genomics 60:295-308(1999) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein."EMBO J. 20:2180-2190(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin."Biochem. Biophys. Res. Commun. 271:719-725(2000) [PubMed] [Europe PMC] [Abstract]
  9. "The GGAs promote ARF-dependent recruitment of clathrin to the TGN."Cell 105:93-102(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains."J. Biol. Chem. 276:28541-28545(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Sorting of mannose 6-phosphate receptors mediated by the GGAs."Science 292:1712-1716(2001) [PubMed] [Europe PMC] [Abstract]
  12. "GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors."Biochem. J. 365:369-378(2002) [PubMed] [Europe PMC] [Abstract]
  13. "The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding."FEBS Lett. 511:155-158(2002) [PubMed] [Europe PMC] [Abstract]
  14. "Interaction of the cation-dependent mannose 6-phosphate receptor with GGA proteins."J. Biol. Chem. 277:18477-18482(2002) [PubMed] [Europe PMC] [Abstract]
  15. "Clint: a novel clathrin-binding ENTH-domain protein at the Golgi."Mol. Biol. Cell 13:4060-4073(2002) [PubMed] [Europe PMC] [Abstract]
  16. "Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins."Biochemistry 42:12174-12180(2003) [PubMed] [Europe PMC] [Abstract]
  17. "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex."EMBO J. 22:78-88(2003) [PubMed] [Europe PMC] [Abstract]
  18. "Binding partners for the COOH-terminal appendage domains of the GGAs and gamma-adaptin."Mol. Biol. Cell 14:2385-2398(2003) [PubMed] [Europe PMC] [Abstract]
  19. "Mammalian GGAs act together to sort mannose 6-phosphate receptors."J. Cell Biol. 163:755-766(2003) [PubMed] [Europe PMC] [Abstract]
  20. "Definition of the consensus motif recognized by gamma-adaptin ear domains."J. Biol. Chem. 279:8018-8028(2004) [PubMed] [Europe PMC] [Abstract]
  21. "Interactions of GGA3 with the ubiquitin sorting machinery."Nat. Cell Biol. 6:244-251(2004) [PubMed] [Europe PMC] [Abstract]
  22. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  24. "Crystal structure of GGA2 VHS domain and its implication in plasticity in the ligand binding pocket."FEBS Lett. 537:171-176(2003) [PubMed] [Europe PMC] [Abstract]