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GTPase Activating Protein And VPS9 Domains 1 (GAPVD1)

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RAP6; GAPEX5; Rab5-activating protein 6; GTPase-activating protein and VPS9 domain-containing protein 1

GTPase Activating Protein And VPS9 Domains 1 (GAPVD1)
CCC L543
HGNC 23375
MGI 1913941
PubMed 16410077
RGD 1307479
UniProt Q14C86
Wiki GAPVD1
GAPVD1 is Rab GTPase guanine nucleotide exchange factor essential for activation of RAB5A during engulfment of apoptotic cells. GAPVD1 is also involved in the degradation of the epidermal growth factor receptor. Gapex-5 mediated activation of Rab5 has been implicated in the insulin stimulated formation of plasma membrane phosphatidylinositol-3-phosphate. The deduced 1,439-amino acid protein has a predicted molecular mass of 158 kD. It contains a C-terminal Vps9-like motif, which is found in other Rab5 GEFs, and an N-terminal RasGAP-like domain (RGD) similar to those found in GAP proteins that specifically interact with Ras proteins. An antibody raised to RAP6 localized the protein to the plasma membrane and intracellular vesicles.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GTPase Activating Protein And VPS9 Domains 1 (GAPVD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GTPase Activating Protein And VPS9 Domains 1 (GAPVD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GTPase Activating Protein And VPS9 Domains 1 (GAPVD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GTPase Activating Protein And VPS9 Domains 1 (GAPVD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for GTPase Activating Protein And VPS9 Domains 1 (GAPVD1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GTPase Activating Protein And VPS9 Domains 1 (GAPVD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GTPase Activating Protein And VPS9 Domains 1 (GAPVD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GTPase Activating Protein And VPS9 Domains 1 (GAPVD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GTPase Activating Protein And VPS9 Domains 1 (GAPVD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for GTPase Activating Protein And VPS9 Domains 1 (GAPVD1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GTPase Activating Protein And VPS9 Domains 1 (GAPVD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GTPase Activating Protein And VPS9 Domains 1 (GAPVD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GTPase Activating Protein And VPS9 Domains 1 (GAPVD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GTPase Activating Protein And VPS9 Domains 1 (GAPVD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for GTPase Activating Protein And VPS9 Domains 1 (GAPVD1) ELISA Kit Customized Service Offer
  1. "Rab5-activating protein 6, a novel endosomal protein with a role in endocytosis."Biochem. Biophys. Res. Commun. 340:967-975(2006) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  8. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  9. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]