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Growth Arrest And DNA Damage Inducible Protein Gamma Interacting Protein 1 (GADD45gIP1)

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CKBBP2; CRIF1; PLINP-1; PRG6; Plinp1; Papillomavirus L2 Interacting Nuclear Protein 1; CKII Beta Binding Protein 2; CR6 Interacting Factor 1; p53-Responsive Gene 6

Growth Arrest And DNA Damage Inducible Protein Gamma Interacting Protein 1 (GADD45gIP1)
CCC L537
HGNC 29996
MGI 1914947
PubMed 17804717
RGD 1309249
UniProt Q8TAE8
Wiki GADD45GIP1
Inactivation of the p53 tumor suppressor protein (TP53) has been observed in a large number of human cancers. Overexpression of p53 induces either growth arrest or apoptosis. The growth arrest function of p53 is mediated by induction of p21 (CDKN1A). PRG6 was downregulated in the apoptotic cells. Northern blot analysis of the colon cancer cell line detected a 0.8-kb PRG6 transcript.
GADD45GIP1 expression suppressed cell growth in human ovarian and cervical cancer cell lines in vitro and in vivo. NAC1 (BTBD14B), which increases the tumorigenicity of ovarian surface epithelial cells and NIH3T3 cells in athymic nu/nu mice, downregulated the expression of endogenous GADD45GIP1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Growth Arrest And DNA Damage Inducible Protein Gamma Interacting Protein 1 (GADD45gIP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Gamma Interacting Protein 1 (GADD45gIP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Gamma Interacting Protein 1 (GADD45gIP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Growth Arrest And DNA Damage Inducible Protein Gamma Interacting Protein 1 (GADD45gIP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Growth Arrest And DNA Damage Inducible Protein Gamma Interacting Protein 1 (GADD45gIP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Growth Arrest And DNA Damage Inducible Protein Gamma Interacting Protein 1 (GADD45gIP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Gamma Interacting Protein 1 (GADD45gIP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Gamma Interacting Protein 1 (GADD45gIP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Growth Arrest And DNA Damage Inducible Protein Gamma Interacting Protein 1 (GADD45gIP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Growth Arrest And DNA Damage Inducible Protein Gamma Interacting Protein 1 (GADD45gIP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Growth Arrest And DNA Damage Inducible Protein Gamma Interacting Protein 1 (GADD45gIP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Gamma Interacting Protein 1 (GADD45gIP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Gamma Interacting Protein 1 (GADD45gIP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Growth Arrest And DNA Damage Inducible Protein Gamma Interacting Protein 1 (GADD45gIP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Growth Arrest And DNA Damage Inducible Protein Gamma Interacting Protein 1 (GADD45gIP1) ELISA Kit Customized Service Offer
  1. "Interaction of human papillomavirus type 16 L2 with cellular proteins: identification of novel nuclear body-associated proteins."Virology 303:69-78(2002) [PubMed] [Europe PMC] [Abstract]
  2. "CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle."J. Biol. Chem. 278:28079-28088(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene."Biochem. Biophys. Res. Commun. 261:864-869(1999) [PubMed] [Europe PMC] [Abstract]
  5. "CR6-interacting factor 1 interacts with orphan nuclear receptor Nur77 and inhibits its transactivation."Mol. Endocrinol. 19:12-24(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis."Nucleic Acids Res. 40:6109-6121(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Identification and characterization of CHCHD1, AURKAIP1, and CRIF1 as new members of the mammalian mitochondrial ribosome."Front. Physiol. 4:183-183(2013) [PubMed] [Europe PMC] [Abstract]