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Bicaudal D Homolog 2 (BICD2)

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Bicaudal D Homolog 2 (BICD2)
CCC L529
HGNC 17208
MGI 1924145
PubMed 23664120
RGD 735093
UniProt Q8TD16
Wiki BICD2
BICD2 is one of two human homologs of Drosophila bicaudal-D and a member of the Bicoid family. It has been implicated in dynein-mediated, minus end-directed motility along microtubules. It has also been reported to be a phosphorylation target of NIMA related kinase 8. Two alternative splice variants have been described.
The deduced 847-amino acid protein shares significant similarity with human BICD1. BICD2 had an apparent molecular mass of 88 kD by SDS-PAGE. RT-PCR detected relatively uniform expression of BICD2 in all tissues examined.rabbit Bicd2 was a substrate for phosphorylation by Nek9, which they called Nek8, in vitro, and that the endogenous proteins associated in vivo. Localization of BICD2 on cytoskeletal structures depended on microtubule morphology.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bicaudal D Homolog 2 (BICD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bicaudal D Homolog 2 (BICD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bicaudal D Homolog 2 (BICD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bicaudal D Homolog 2 (BICD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bicaudal D Homolog 2 (BICD2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bicaudal D Homolog 2 (BICD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bicaudal D Homolog 2 (BICD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bicaudal D Homolog 2 (BICD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bicaudal D Homolog 2 (BICD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bicaudal D Homolog 2 (BICD2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bicaudal D Homolog 2 (BICD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bicaudal D Homolog 2 (BICD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bicaudal D Homolog 2 (BICD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bicaudal D Homolog 2 (BICD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bicaudal D Homolog 2 (BICD2) ELISA Kit Customized Service Offer
  1. "Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2."J. Biol. Chem. 277:16229-16240(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Novel mutations in the DYNC1H1 tail domain refine the genetic and clinical spectrum of dyneinopathies."Hum. Mutat. 36:287-291(2015) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Molecular defects in the motor adaptor BICD2 cause proximal spinal muscular atrophy with autosomal-dominant inheritance."Am. J. Hum. Genet. 92:955-964(2013) [PubMed] [Europe PMC] [Abstract]
  18. "Mutations in BICD2 cause dominant congenital spinal muscular atrophy and hereditary spastic paraplegia." Am. J. Hum. Genet. 92:965-973(2013) [PubMed] [Europe PMC] [Abstract]
  19. "Mutations in BICD2, which encodes a golgin and important motor adaptor, cause congenital autosomal-dominant spinal muscular atrophy." Am. J. Hum. Genet. 92:946-954(2013) [PubMed] [Europe PMC] [Abstract]