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PLM encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity. Transcript variants with different 5' UTR sequences have been described in the literature.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Phospholemman (PLM) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Phospholemman (PLM) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Phospholemman (PLM) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Phospholemman (PLM) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Phospholemman (PLM) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Phospholemman (PLM) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Phospholemman (PLM) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Phospholemman (PLM) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Phospholemman (PLM) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Phospholemman (PLM) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Phospholemman (PLM) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Phospholemman (PLM) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Phospholemman (PLM) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Phospholemman (PLM) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Phospholemman (PLM) | ELISA Kit Customized Service Offer |
- "Characterization of the human and rat phospholemman (PLM) cDNAs and localization of the human PLM gene to chromosome 19q13.1."Genomics 41:435-443(1997) [PubMed] [Europe PMC] [Abstract]
- "The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression."Genomics 68:41-56(2000) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Phospholemman is a substrate for myotonic dystrophy protein kinase."J. Biol. Chem. 275:23362-23367(2000) [PubMed] [Europe PMC] [Abstract]
- "The inhibitory effect of phospholemman on the sodium pump requires its palmitoylation."J. Biol. Chem. 286:36020-36031(2011) [PubMed] [Europe PMC] [Abstract]