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Formin Homology 2 Domain Containing Protein 1 (FHOD1)

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FHOS; FH1/FH2 Domain Containing Protein; Formin homolog overexpressed in spleen 1

Formin Homology 2 Domain Containing Protein 1 (FHOD1)
CCC L522
HGNC 17905
MGI 2679008
PubMed 18239683
RGD 1589776
UniProt Q9Y613
Wiki FHOD1
FHOD1 is a member of the formin/diaphanous family of proteins.FHOD1 is ubiquitously expressed but is found in abundance in the spleen.FHOD1 has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines.The full-length clone was obtained by screening a Burkitt lymphoma cell line and human fetal and adult spleen cDNA libraries with the partial cDNA. The deduced 1,165-amino acid protein has a calculated molecular mass of 128 kD and shows sequence homology to Diaphanous and FMN1 within the FH1 and FH2 domains.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Formin Homology 2 Domain Containing Protein 1 (FHOD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Formin Homology 2 Domain Containing Protein 1 (FHOD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Formin Homology 2 Domain Containing Protein 1 (FHOD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Formin Homology 2 Domain Containing Protein 1 (FHOD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Formin Homology 2 Domain Containing Protein 1 (FHOD1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Formin Homology 2 Domain Containing Protein 1 (FHOD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Formin Homology 2 Domain Containing Protein 1 (FHOD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Formin Homology 2 Domain Containing Protein 1 (FHOD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Formin Homology 2 Domain Containing Protein 1 (FHOD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Formin Homology 2 Domain Containing Protein 1 (FHOD1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Formin Homology 2 Domain Containing Protein 1 (FHOD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Formin Homology 2 Domain Containing Protein 1 (FHOD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Formin Homology 2 Domain Containing Protein 1 (FHOD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Formin Homology 2 Domain Containing Protein 1 (FHOD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Formin Homology 2 Domain Containing Protein 1 (FHOD1) ELISA Kit Customized Service Offer
  1. "Identification and characterization of a protein containing formin homology (FH1/FH2) domains."Gene 232:173-182(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Fhos, a mammalian formin, directly binds to F-actin via a region N-terminal to the FH1 domain and forms a homotypic complex via the FH2 domain to promote actin fiber formation."J. Cell Sci. 116:4567-4575(2003) [PubMed] [Europe PMC] [Abstract]
  3. "EBV attachment stimulates FHOS/FHOD1 redistribution and co-aggregation with CD21: formin interactions with the cytoplasmic domain of human CD21."J. Cell Sci. 117:2709-2720(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  6. "FHOD1 coordinates actin filament and microtubule alignment to mediate cell elongation."Exp. Cell Res. 306:192-202(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Biochemical characterization of the diaphanous autoregulatory interaction in the formin homology protein FHOD1."J. Biol. Chem. 281:5084-5093(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The diaphanous-related formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing."J. Biol. Chem. 283:27891-27903(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]