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Kindlin 2 (KIND2)

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PLEKHC1; FERMT2; MIG2; UNC112; Pleckstrin Homology Domain Containing Family C Member 1; Fermitin Family Homolog 2; Mitogen-inducible gene 2 protein

Kindlin 2 (KIND2)
CCC L519
HGNC 15767
MGI 2385001
PubMed 19854292
RGD 1311799
UniProt Q96AC1
Wiki PLEKHC1
FERMT2 is a component of extracellular matrix structures in mammalian cells and is required for proper control of cell shape change.MIG2 is transcribed from the opposite strand of the gene encoding transcription factor HTF4.The MIG2 protein shares significant homology with C. elegans Unc112, a novel FERM domain-containing protein that is essential for the assembly of integrin-containing muscle attachment structures.
migfilin interacts with MIG2 and the actin-binding protein filamin through its C- and N-terminal domains, respectively. Loss of MIG2 or migfilin impaired cell shape modulation. The authors determined that MIG2 recruits migfilin to cell-ECM adhesions, while the migfilin-filamin interaction mediates the association of migfilin with actin filaments.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kindlin 2 (KIND2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kindlin 2 (KIND2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kindlin 2 (KIND2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kindlin 2 (KIND2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kindlin 2 (KIND2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kindlin 2 (KIND2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kindlin 2 (KIND2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kindlin 2 (KIND2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kindlin 2 (KIND2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kindlin 2 (KIND2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kindlin 2 (KIND2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kindlin 2 (KIND2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kindlin 2 (KIND2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kindlin 2 (KIND2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kindlin 2 (KIND2) ELISA Kit Customized Service Offer
  1. "Identification of serum-inducible genes: different patterns of gene regulation during G0->S and G1->S progression."J. Cell Sci. 107:227-239(1994) [PubMed] [Europe PMC] [Abstract]
  2. "URP1: a member of a novel family of PH and FERM domain-containing membrane-associated proteins is significantly over-expressed in lung and colon carcinomas."Biochim. Biophys. Acta 1637:207-216(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation."Cell 113:37-47(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Kindlin-2 (Mig-2): a co-activator of beta3 integrins."J. Cell Biol. 181:439-446(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Osteoblast mineralization requires beta1 integrin/ICAP-1-dependent fibronectin deposition."J. Cell Biol. 194:307-322(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins."J. Cell Sci. 124:879-891(2011) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Kindlin 2 forms a transcriptional complex with beta-catenin and TCF4 to enhance Wnt signalling."EMBO Rep. 13:750-758(2012) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "Structural basis of phosphoinositide binding to kindlin-2 protein pleckstrin homology domain in regulating integrin activation."J. Biol. Chem. 286:43334-43342(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Membrane binding of the N-terminal ubiquitin-like domain of kindlin-2 is crucial for its regulation of integrin activation."Structure 19:1664-1671(2011) [PubMed] [Europe PMC] [Abstract]
  20. "Crystal structure of kindlin-2 PH domain reveals a conformational transition for its membrane anchoring and regulation of integrin activation."Protein Cell 3:434-440(2012) [PubMed] [Europe PMC] [Abstract]