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FCH Domain Only Protein 2 (FCHO2)

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F-BAR domain only protein 2

FCH Domain Only Protein 2 (FCHO2)
CCC L516
HGNC 25180
MGI 3505790
PubMed 21762413
RGD 1565396
UniProt Q0JRZ9
Wiki FCHO2
The deduced 810-amino acid protein contains an N-terminal FCH domain and an evolutionarily conserved C-terminal FCHO homology (FOH) domain. FCHO2 shares 94.6% identity with mouse Fcho2 and 50.4% identity with human FCHO1.The membrane-sculpting F-BAR domain-containing Fer/Cip4 homology domain-only proteins 1 and 2 (FCHO1/2) are required for plasma membrane clathrin-coated vesicle (CCV) budding and marked sites of CCV formation. Changes in FCHO1/2 expression levels correlated directly with numbers of CCV budding events, ligand endocytosis, and synaptic vesicle marker recycling. FCHO1/2 proteins bound specifically to the plasma membrane and recruited the scaffold proteins eps15 and intersectin, which in turn engaged the adaptor complex AP2.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant FCH Domain Only Protein 2 (FCHO2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to FCH Domain Only Protein 2 (FCHO2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to FCH Domain Only Protein 2 (FCHO2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for FCH Domain Only Protein 2 (FCHO2) CLIA Kit Customized Service Offer
n/a ELISA Kit for FCH Domain Only Protein 2 (FCHO2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant FCH Domain Only Protein 2 (FCHO2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to FCH Domain Only Protein 2 (FCHO2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to FCH Domain Only Protein 2 (FCHO2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for FCH Domain Only Protein 2 (FCHO2) CLIA Kit Customized Service Offer
n/a ELISA Kit for FCH Domain Only Protein 2 (FCHO2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant FCH Domain Only Protein 2 (FCHO2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to FCH Domain Only Protein 2 (FCHO2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to FCH Domain Only Protein 2 (FCHO2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for FCH Domain Only Protein 2 (FCHO2) CLIA Kit Customized Service Offer
n/a ELISA Kit for FCH Domain Only Protein 2 (FCHO2) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "FCHo proteins are nucleators of clathrin-mediated endocytosis."Science 328:1281-1284(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Characterization of the EFC/F-BAR domain protein, FCHO2."Genes Cells 16:868-878(2011) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis."Mol. Biol. Cell 23:1330-1342(2012) [PubMed] [Europe PMC] [Abstract]
  14. "Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning."Nat. Cell Biol. 14:488-501(2012) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Structure and analysis of FCHo2 F-BAR domain: a dimerizing and membrane recruitment module that effects membrane curvature."Structure 15:839-852(2007) [PubMed] [Europe PMC] [Abstract]