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F-Box And WD Repeat Domain Containing Protein 11 (FBXW11)

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BTRC2; BTRCP2; FBW1B; FBXW1B; Fbw11; Hos; Homologous to Slimb protein; F-box and WD repeats protein beta-TrCP2; F-box/WD repeat-containing protein 1B

F-Box And WD Repeat Domain Containing Protein 11 (FBXW11)
CCC L515
HGNC 13607
MGI 2144023
PubMed 16865294
RGD 1309121
UniProt Q9UKB1
Wiki FBXW11
FBXW11 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant F-Box And WD Repeat Domain Containing Protein 11 (FBXW11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to F-Box And WD Repeat Domain Containing Protein 11 (FBXW11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to F-Box And WD Repeat Domain Containing Protein 11 (FBXW11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for F-Box And WD Repeat Domain Containing Protein 11 (FBXW11) CLIA Kit Customized Service Offer
n/a ELISA Kit for F-Box And WD Repeat Domain Containing Protein 11 (FBXW11) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant F-Box And WD Repeat Domain Containing Protein 11 (FBXW11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to F-Box And WD Repeat Domain Containing Protein 11 (FBXW11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to F-Box And WD Repeat Domain Containing Protein 11 (FBXW11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for F-Box And WD Repeat Domain Containing Protein 11 (FBXW11) CLIA Kit Customized Service Offer
n/a ELISA Kit for F-Box And WD Repeat Domain Containing Protein 11 (FBXW11) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant F-Box And WD Repeat Domain Containing Protein 11 (FBXW11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to F-Box And WD Repeat Domain Containing Protein 11 (FBXW11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to F-Box And WD Repeat Domain Containing Protein 11 (FBXW11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for F-Box And WD Repeat Domain Containing Protein 11 (FBXW11) CLIA Kit Customized Service Offer
n/a ELISA Kit for F-Box And WD Repeat Domain Containing Protein 11 (FBXW11) ELISA Kit Customized Service Offer
  1. "Identification of a family of human F-box proteins."Curr. Biol. 9:1177-1179(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and genomic structure of the betaTRCP2 gene on chromosome 5q35.1."Biochem. Biophys. Res. Commun. 269:103-109(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "IkappaBalpha ubiquitination is catalyzed by an SCF-like complex containing Skp1, cullin-1, and two F-box/WD40-repeat proteins, betaTrCP1 and betaTrCP2."Biochem. Biophys. Res. Commun. 256:127-132(1999) [PubMed] [Europe PMC] [Abstract]
  7. "HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin."Oncogene 18:2039-2046(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination."J. Biol. Chem. 275:2877-2884(2000) [PubMed] [Europe PMC] [Abstract]
  9. "SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor."EMBO J. 22:5480-5490(2003) [PubMed] [Europe PMC] [Abstract]
  10. "A complex containing betaTrCP recruits Cdc34 to catalyse ubiquitination of IkappaBalpha."FEBS Lett. 455:311-314(1999) [PubMed] [Europe PMC] [Abstract]
  11. "Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein."Mol. Cell. Biol. 26:5994-6004(2006) [PubMed] [Europe PMC] [Abstract]
  12. "The SCF(HOS/beta-TRCP)-ROC1 E3 ubiquitin ligase utilizes two distinct domains within CUL1 for substrate targeting and ubiquitin ligation."Mol. Cell. Biol. 20:1382-1393(2000) [PubMed] [Europe PMC] [Abstract]
  13. "Inhibition of HOS expression and activities by Wnt pathway."Oncogene 21:856-860(2002) [PubMed] [Europe PMC] [Abstract]
  14. "Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage."Nature 426:87-91(2003) [PubMed] [Europe PMC] [Abstract]
  15. "SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein."J. Biol. Chem. 280:26863-26872(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Oxidative stress-induced ubiquitination of RCAN1 mediated by SCFbeta-TrCP ubiquitin ligase."Int. J. Mol. Med. 22:95-104(2008) [PubMed] [Europe PMC] [Abstract]
  17. "HIV-1 Vpu neutralizes the antiviral factor Tetherin/BST-2 by binding it and directing its beta-TrCP2-dependent degradation."PLoS Pathog. 5:E1000574-E1000574(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate."Mol. Cell 37:784-796(2010) [PubMed] [Europe PMC] [Abstract]
  19. "The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival."Oncogene 29:1384-1393(2010) [PubMed] [Europe PMC] [Abstract]