Frequently Rearranged In Advanced T-Cell Lymphomas 2 (FRAT2)

FRAT2 belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression.

The deduced 233-amino acid protein, which is 77% identical to FRAT1, contains an N-terminal acidic domain followed by a proline-rich domain and a GSK3B-binding domain near the C terminus, which is highly divergent from that of FRAT1. Northern blot analysis detected a 2.4-kb transcript, with highest expression in pancreas, heart, spleen, placenta, skeletal muscle, liver, peripheral blood leukocytes, and fetal kidney. Expression was higher in gastric cancer, cervical cancer, and chronic myelogenous leukemia cell lines than in other cancer cell lines.