≡

Endogenous Retroviral Sequence 3 (ERV3)

[Edit]

H-PLK; HERV-R; Envelope polyprotein; HERV-R envelope protein; HERV-R_7q21.2 Provirus Ancestral Env Polyprotein; Includes Zinc Finger Protein H-plk/HPF9

Endogenous Retroviral Sequence 3 (ERV3)
CCC L505
HGNC 3454
PubMed 12083821
UniProt Q14264
Wiki ERV3
The human genome includes many retroelements including the human endogenous retroviruses (HERVs). ERV3, one of the most studied HERVs, is thought to have integrated 30 to 40 million years ago and is present in higher primates with the exception of gorillas. Taken together, the observation of genome conservation, the detection of transcript expression, and the presence of conserved ORFs is circumstantial evidence for a functional role. A functional role is also suggested by the observation that downregulation of ERV3 is reported in choriocarcinoma.DNA sequencing of the human provirus and comparisons with other retroviruses showed that ERV3 contains gag and pol gene sequences that are significantly related to mammalian type C retroviruses and endogenous proviruses. In mouse, endogenous provirus DNA comprises up to 0.4% of the total genome.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Endogenous Retroviral Sequence 3 (ERV3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Endogenous Retroviral Sequence 3 (ERV3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Endogenous Retroviral Sequence 3 (ERV3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Endogenous Retroviral Sequence 3 (ERV3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Endogenous Retroviral Sequence 3 (ERV3) ELISA Kit Customized Service Offer
  1. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The nucleotide sequence of the env gene from the human provirus ERV3 and isolation and characterization of an ERV3-specific cDNA."Virology 147:449-458(1985) [PubMed] [Europe PMC] [Abstract]
  3. "Abundance of an endogenous retroviral envelope protein in placental trophoblasts suggests a biological function."Virology 211:589-592(1995) [PubMed] [Europe PMC] [Abstract]
  4. "The cellular mechanism by which the human endogenous retrovirus ERV-3 env gene affects proliferation and differentiation in a human placental trophoblast model, BeWo."Placenta 21:73-78(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution."Proc. Natl. Acad. Sci. U.S.A. 100:13013-13018(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins."J. Virol. 77:10414-10422(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Developmental expression of HERV-R (ERV3) and HERV-K in human tissue."Virology 297:220-225(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Physiological knockout of the envelope gene of the single-copy ERV-3 human endogenous retrovirus in a fraction of the Caucasian population."J. Virol. 72:3442-3445(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Large number of polymorphic nucleotides and a termination codon in the env gene of the endogenous human retrovirus ERV3."Dis. Markers 14:127-133(1998) [PubMed] [Europe PMC] [Abstract]