≡

Enabled Homolog (ENAH)

[Edit]

NDPP1; MENA

Enabled Homolog (ENAH)
CCC L497
HGNC 18271
MGI 108360
PubMed 24213538
RGD 1307666
UniProt Q8N8S7
Wiki ENAH
Enah, called Ndpp1The 3-prime UTR contains 7 ATTTA mRNA destabilization motifs. The deduced 389-amino acid protein has a proline-rich N terminus, followed by a leucine/proline-rich region, a 4-arginine cluster near a possible alpha helix, and a second possible alpha helix at the C terminus. Enah also has 3 putative N-glycosylation sites. Northern blot analysis detected a number of mRNA species that were downregulated during mouse embryonic development and were only faintly detected in adult mouse brain. Southern blot analysis of RT-PCR products found Enah expressed in several adult mouse tissues, with highest expression in heart and testis. Southern blot analysis detected homologs of mouse Enah in several vertebrate species, including human.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Enabled Homolog (ENAH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Enabled Homolog (ENAH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Enabled Homolog (ENAH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Enabled Homolog (ENAH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Enabled Homolog (ENAH) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Enabled Homolog (ENAH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Enabled Homolog (ENAH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Enabled Homolog (ENAH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Enabled Homolog (ENAH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Enabled Homolog (ENAH) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Enabled Homolog (ENAH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Enabled Homolog (ENAH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Enabled Homolog (ENAH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Enabled Homolog (ENAH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Enabled Homolog (ENAH) ELISA Kit Customized Service Offer
  1. "Human Mena protein, a serex-defined antigen overexpressed in breast cancer eliciting both humoral and CD8+ T-cell immune response."Int. J. Cancer 109:909-918(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Splicing program of human MENA produces a previously undescribed isoform associated with invasive, mesenchymal-like breast tumors."Proc. Natl. Acad. Sci. U.S.A. 109:19280-19285(2012) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex."Curr. Biol. 11:1645-1655(2001) [PubMed] [Europe PMC] [Abstract]
  8. "A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family."EMBO J. 16:5433-5444(1997) [PubMed] [Europe PMC] [Abstract]
  9. "Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins."J. Biol. Chem. 275:22503-22511(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Robo4 is a vascular-specific receptor that inhibits endothelial migration."Dev. Biol. 261:251-267(2003) [PubMed] [Europe PMC] [Abstract]
  11. "RIAM, an Ena/VASP and profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion."Dev. Cell 7:585-595(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics."Dev. Cell 7:571-583(2004) [PubMed] [Europe PMC] [Abstract]
  13. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  19. "Structural basis for polyproline recognition by the FE65 WW domain."J. Mol. Biol. 372:970-980(2007) [PubMed] [Europe PMC] [Abstract]
  20. "Tes, a specific Mena interacting partner, breaks the rules for EVH1 binding."Mol. Cell 28:1071-1082(2007) [PubMed] [Europe PMC] [Abstract]
  21. "Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A."J. Biol. Chem. 286:11543-11554(2011) [PubMed] [Europe PMC] [Abstract]