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Elongation Of Very Long Chain Fatty Acids Like Protein 5 (ELOVL5)

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HELO1; ELOVL2; FEN1/Elo2,SUR4/Elo3-Like; ELOVL fatty acid elongase 5; Fatty acid elongase 1; Very-long-chain 3-oxoacyl-CoA synthase 5; 3-keto acyl-CoA synthase ELOVL5

Elongation Of Very Long Chain Fatty Acids Like Protein 5 (ELOVL5)
CCC L493
HGNC 21308
MGI 1916051
PubMed 18838740
RGD 620583
UniProt Q9NYP7
Wiki ELOVL5
ELOVL5 plays a role in elongation of long-chain polyunsaturated fatty acids.By database analysis using Saccharomyces cerevisiae Elo2 sequence as query, followed by PCR of a human liver cDNA library, Leonard et al. (2000) cloned ELOVL5, which they called HELO1. The deduced 299-amino acid protein contains 6 transmembrane regions and a histidine box, characteristic of membrane-bound enzymes. Quantitative RT-PCR analysis of human tissues detected highest expression testis and adrenal gland with lower expression in brain, lung, prostate, mammary gland, thymus, and fetal liver.Leonard et al. (2000) showed that ELOVL5 expressed in yeast catalyzed the elongation of the polyunsaturated fatty acid substrate gamma-linolenic acid (GLA) and several other long-chain polyunsaturated fatty acids.

Organism species: Homo sapiens (Human)

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Organism species: Mus musculus (Mouse)

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Organism species: Rattus norvegicus (Rat)

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  1. "Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids."Biochem. J. 350:765-770(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis."Proc. Natl. Acad. Sci. U.S.A. 107:18439-18444(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "ELOVL5 mutations cause spinocerebellar ataxia 38." Am. J. Hum. Genet. 95:209-217(2014) [PubMed] [Europe PMC] [Abstract]